Stem Cell Biology and Plasticity

  • Emin Kansu
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 534)


Multipotent stem cells are found in mature tissues and are formed by the body to replace worn out cells in tissues and organs. Stem cells in the bone marrow, called hematopoietic stem cells form the various kinds of blood cells. Neural stem cells form the brain and central nervous system. Mesenchymal stem cells form fat, bone, muscle and cartilage. Multipotent stem cells are sometimes called somatic or adult stem cells.


Stem Cell Mesenchymal Stem Cell Embryonic Stem Cell Human Embryonic Stem Cell Adult Stem Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Jouneau, A., and Renard J.P., 2002, Cellules souches embryonnaires et clonage therapeutique.Medecine et Sciences 18169–180.Google Scholar
  2. 2.
    Weissman, I.L., 2000, Stem cells: units of development, units of regeneration and units in evolution.Cell 100157–168.CrossRefGoogle Scholar
  3. 3.
    Thompson, E.M., Legouy, E., and Renard, J.P. 1998, Mouse embryos do not wait for the BMT: chromatin and RNA polymerasere modeling in genome activation at the on set of development.Dev. Genet. 2231–42.CrossRefGoogle Scholar
  4. 4.
    Cibelli, J.B., Kiessling, A.A., Cunniff, K., Richards, C., Lanza, R., and West, M. 2001, Somatic cell nuclear transfer in humans: Pronuclear and early embryonic development.Regen. Med. 225–31.Google Scholar
  5. 5.
    Moore, al.1997, In-vitro maintenance of highly purified, transplantable hematopoietic stem cells.Blood 894337–4347.Google Scholar
  6. 6.
    McDonald, al.1999, Transplanted embryonic stem cells survive, differentiate and promote recovery in injured spinal cord.Nature Med 51410–1412.CrossRefGoogle Scholar
  7. 7.
    Jackson, al.1999, Hematopoietic potential of stem cells isolated from murine skeletal muscle.Proc. Natl. Acad. Sci. USA 9614482–14486.CrossRefGoogle Scholar
  8. 8.
    Keller, G., and Snodgrass, H.R., 1999, Human embryonic stem cells. The future is now.Nature Med.5, 151–153.CrossRefGoogle Scholar
  9. 9.
    Annas, al.1999, Stem cell politics, ethics and medical progress.Nature Med. 51339–1341.CrossRefGoogle Scholar
  10. 10.
    Phillips, al.2000, The genetic program of hematopoietic stem cells.Science 2881635–1640.CrossRefGoogle Scholar
  11. 11.
    Lagasse, al.2000, Purified hematopoietic stem cells can differentiate into hepatocytesin vivo. Nature Med 61229–1234.CrossRefGoogle Scholar
  12. 12.
    Orkin, S.H., 2000, Stem cell alchemy.Nature Med 61212–1213.CrossRefGoogle Scholar
  13. 13.
    Stem cell research and therapeutic cloning: an update. The Royal Society publication. Policy Document/November 2000.Google Scholar
  14. 14.
    Mieth D. Going to the roots of the stem cell debate. The ethical problems of using embryos for research.EMBO Reports 14–6, 2000. Silver LM. Reprogenetics: Third millenium speculation. The consequences for humanity when reproductive biology and genetics are combined.EMBO Reports 1375–378, 2000.CrossRefGoogle Scholar
  15. 15.
    The use of embryonic stem cells in therapeutic research. Report of the International Bioethics Committee on the ethical aspects of human embryonic stem cell research. April 2000.Google Scholar
  16. 16.
    Odorico, al.2001, Multilineage differentiation from human embryonic stem cell lines.Stem Cells 19193–204.CrossRefGoogle Scholar
  17. 17.
    Orlic, al.2001, Bone marrow cells regenerate infarcted myocardium.Nature 410701–705.CrossRefGoogle Scholar
  18. 18.
    Theise, al.2001, Liver from bone marrow in humans.Hepatology 3211–16.CrossRefGoogle Scholar
  19. 19.
    Lebkowski, al.2001, Human embryonic stem cells: culture, differentiation, and genetic modification for regenerative medicine applications.Cancer J. 7(Suppl. 2), 583–594.Google Scholar
  20. 20.
    Bianco, al.2001, Bone marrow stromal cells: nature, biology, and potential applications.Stem Cells 19180–192.CrossRefGoogle Scholar
  21. 21.
    Yoder, M.C., 2001, Spatial origin of murine hematopoietic stem cells.Blood 983–5.CrossRefGoogle Scholar
  22. 22.
    Hao, Q-Linet al.2001, Identification of a novel human multilymphoid progenitor in cord blood.Blood 973683–3690.CrossRefGoogle Scholar
  23. 23.
    Vogel, G., 2001, Rumors and trial balloons precende Bush’s funding decision.Science 293186–187.CrossRefGoogle Scholar
  24. 24.
    Report of the Committee on the Biological and BioMedical Applications of Stem Cell Research. National Academy of Sciences USA Washington, D.C. June 2001.Google Scholar
  25. 25.
    Colman, A., and Burley, J.C., 2001, A legal and ethical tightrope. Science, ethics and legislation of stem cell research.EMBO Reports 22–5.CrossRefGoogle Scholar
  26. 26.
    Cibelli, J.B., Lanza, R.P., West, M.D., and Ezzell, C., 2001, The first human cloned embryo.Scientific AmericanNovember 24.Google Scholar
  27. 27.
    Lachmann, P., 2001, Stem Cell Research Second Update. The Royal Society Policy Document. September 2001. Stem cell research-why is it regarded as a threat ? An investigation of the economic and ethical arguments made against research with embryonic stem cells.EMBO Reports 2165–168.CrossRefGoogle Scholar
  28. 28.
    Bush draws a stem cell line. Newsweek, August 20, 2001.Google Scholar
  29. 29.
    Stem cells and future of regenerative medicine. Committee on the Biological and Biomedical Applications of Stem Cell Research, Board on Life Sciences-National Research Council and Board on Neuroscience and Behavioral Health-Institute of Medicine. Washington, D.C. National Academy Press, 2002.Google Scholar
  30. 30.
    Panel on Scientific and Medical Aspects of Human Reproductive Cloning. Scientific and medical aspects of human reproductive cloning. Washington, D.C. Natural Academy Press, 2002.Google Scholar
  31. 31.
    Weissman, I.L., 2002, Stem cells-scientific, medical and political Issues.New Engl. J. Med. 3461576–1579.CrossRefGoogle Scholar
  32. 32.
    Evers, K., 2002, European perspectives on therapeutic cloning.New Engl. J. Med. 3461579–1582.CrossRefGoogle Scholar
  33. 33.
    KSrbling, M., Katz, R.L., Khanna, A., Ruifrok, al.2002, Hepatocytes and epithelial cells of donor origin in recipients of peripheral-blood stem cells.New Engl. J. Med. 346738–746.CrossRefGoogle Scholar
  34. 34.
    Jiang, Y., Jahagirdar, B.N., Reinhardt, R.L., Schwartz, al.2002, Pluripotency of mesenchymal stem stem cells derived from adult marrow.Nature20 June 2002, 1–8.CrossRefGoogle Scholar
  35. 35.
    . NIH ReportNIH Strategies for Implementing Human Embryonic Stem Cell Research. March 8, 2002.Google Scholar
  36. 36.
    . ASH ReportHematology advocates urge congress to keep stem cell research avenues open. April 25, 2002.Google Scholar
  37. 37.
    Regulation of embryonic stem cell research update.ISCT Newsletter9 (1), 17, March 2002.Google Scholar

Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Emin Kansu
    • 1
  1. 1.Institute of OncologyHacettepe UniversityAnkaraTurkey

Personalised recommendations