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Tissue Engineering, Stem Cells, and Gene Therapies pp 327–334Cite as

Detection of Phage Displayed Peptides with Blocking Ability in Vascular Endothelial Growth Factor (VEGF) Model

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 534))

Abstract

Vascular endothelial growth factor (VEGF) is a prime regulator of angiogenesis, vasculogenesis and vascular permeability. Structurally VEGF is a homodimeric protein in which the monomers are linked by a pair of disulfide bonds. Six isoforms of VEGF which have 121, 145, 165, 183, 189 or 206 residues in each monomer are expressed in humans. These isoforms of VEGF appear by a different splicing process. VEGF165is the predominant molecular species, but transcripts encoding VEGF189 are also commonly found in cells expressing the VEGF gene. High levels of VEGF expression have been found in several types of human tumor. In animal models, overexpression of VEGF has been showed to enhance tumor growth whereas suppression of VEGF inhibited tumor growth in several types of tumor

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Author information

Authors and Affiliations

  1. The Scientific and Technical Research Council of Turkey (TUBITAK), Research Institute for Genetic Engineering and Biotechnology, Gebze, Kocaeli, Turkey

    Berrin Erdağ, B. Koray Balcioğlu, Asli Kumbasar & Beyazit Çirakoğlu

  2. School of Medicine, Marmara University, Haydarpasa, İstanbul, Turkey

    Beyazit Çirakoğlu

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  1. Berrin Erdağ
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  2. B. Koray Balcioğlu
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  3. Asli Kumbasar
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  4. Beyazit Çirakoğlu
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Editors and Affiliations

  1. Science Faculty and Biotechnology Institute, Ankara University, Ankara, Turkey

    Y. Murat Elçin

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© 2003 Springer Science+Business Media New York

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Erdağ, B., Balcioğlu, B.K., Kumbasar, A., Çirakoğlu, B. (2003). Detection of Phage Displayed Peptides with Blocking Ability in Vascular Endothelial Growth Factor (VEGF) Model. In: Elçin, Y.M. (eds) Tissue Engineering, Stem Cells, and Gene Therapies. Advances in Experimental Medicine and Biology, vol 534. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0063-6_24

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  • DOI: https://doi.org/10.1007/978-1-4615-0063-6_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4907-5

  • Online ISBN: 978-1-4615-0063-6

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