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Pharmaceutical Applications of In Vivo EPR

  • Karsten Mäder
  • Bernard Gallez
Part of the Biological Magnetic Resonance book series (BIMR, volume 18)

Abstract

This chapter illustrates the potential of In vivo EPR in several areas of pharmaceutical sciences: pharmaceutical technology, pharmacodynamics, toxicology, and pharmacokinetics. This method offers unique opportunities to characterise delivery processes. It provides information about the microenvironment inside the drug carriers (microviscosity, micropolarity, microacidity) and permits the quantitative characterisation of release mechanisms. Localised information can be obtained by means of different nitroxide isotopes or by EPR imaging. Gamma sterilisation derived radicals may serve as endogenous signals to monitor water penetration in clinically used drug carriers. EPR is capable to characterise metabolic processes and to follow the pharmacokinetics of nitroxides and metal ions noninvasively in vivo. Pharmacodynamic applications are related to the measurements of the oxygen level, the microacidity and the level of nitric oxide.

Keywords

Nitric Oxide Electron Paramagnetic Resonance Drug Release Drug Carrier Isosorbide Dinitrate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Karsten Mäder
    • 1
    • 2
  • Bernard Gallez
    • 1
    • 2
  1. 1.Department of Pharmaceutical SciencesFree UniversityBerlinGermany
  2. 2.Laboratory of Medicinal Chemistry and Radiopharmacy, Laboratory of Biomedical Magnetic ResonanceUniversité Catholique de LouvainBrusselsBelgium

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