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Tropical Diseases pp 19–36Cite as

Mitochondrial Genome and Susceptibility to Diabetes Mellitus

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 531))

Abstract

Diabetes mellitus (DM) is a complex polygenic disorder, characterized by a disturbance in insulin production by the pancreatic ß cell or in the ability of target tissues to respond to insulin. While this disorder is not normally regarded to be a disease of the tropics, several factors indeed suggest that it is an emerging health problem in fast-developing countries such as Indonesia. Adult-onset non-insulin-dependent or type 2 DM (NIDDM), in particular, clearly demonstrates the interplay between genetic and nutritional factors in the pathogenesis of the disorder. The progressive transition from a traditional to an industrial life-style, characteristic of fast-developing countries, is associated with an increasing prevalence of NIDDM. The very concept of thrifty gene(s) for energy metabolism (see Kagawa et al., 2002 for a recent review), proposed to save energy during famine but detrimental to an affluent life-style and thus predisposing to DM would predict a high prevalence of such gene(s) in the Southeast Asian archipelago, following the trail of ancient human migrations to the Pacific where the effect of the proposed thrifty gene(s) is most prominently seen (such as in the Nauruan population [Neel, 1999]).

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Authors and Affiliations

  1. Eijkman Institute for Molecular Biology, Jl. Diponegoro 69, Indonesia

    Herawati Sudoyo, Helena Suryadi, Neny Sitorus & Sangkot Marzuki

  2. Department of Internal Medicine, School of Medicine, University of Indonesia, Jl. Salemba, 10430, Jakarta, Indonesia

    Sidartawan Soegondo

  3. Department of Internal Medicine, University of Airlangga, Jl. Darmahusada 47, Surabaya, Indonesia

    Agung Pranoto

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  1. Herawati Sudoyo
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  2. Helena Suryadi
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  4. Sidartawan Soegondo
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  1. Eijkman Institute for Molecular Biology, Jakarta, Indonesia

    Sangkot Marzuki

  2. Eijkman-Winkler Centre, University Medical Centre Utrecht, Utrecht, The Netherlands

    Jan Verhoef  & Harm Snippe  & 

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Sudoyo, H., Suryadi, H., Sitorus, N., Soegondo, S., Pranoto, A., Marzuki, S. (2003). Mitochondrial Genome and Susceptibility to Diabetes Mellitus. In: Marzuki, S., Verhoef, J., Snippe, H. (eds) Tropical Diseases. Advances in Experimental Medicine and Biology, vol 531. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0059-9_2

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