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Vaccines for Pseudomonas aeruginosa

  • Gregory P. Priebe
  • Gerald B. Pier
Part of the Medical Intelligence Unit book series (MIUN)

Abstract

Pseudomonas aeruginosa causes a wide variety of serious infections, particularly in the critically ill,1,2 the immunocompromised,3,4 and those with cystic fibrosis.5 It also JL causes community-acquired bacterial ulcerative keratitis of the eye, particularly in users of extended-wear contact lenses.6,7 In the setting of nosocomial pneumonia, the isolation of P. aeruginosa has a strikingly high attributable mortality.8 The prevalence and importance of P aeruginosa in human infections, coupled with the intrinsic antibiotic resistance due to the low permeability of the outer membrane 9 and the presence of multiple drug efflux pumps,10 confer a pressing need for effective vaccines. A large variety of antigenic targets and delivery methods have been used in many preclinical studies of P. aeruginosa vaccines, and there has also been a number of actual human trials. The failure to have an effective vaccine at this time point can be attributed to a large number of factors. The overwhelming issues appear to encompass the wide variety of often redundant virulence factors that render ineffective approaches that target a single or even a few bacterial products; the antigenic and immunogenic properties of the major target of protective immunity, the O antigen of the lipopolysaccharide (LPS); the ability of the organism to have both extracellular and intracellular stages; and an incomplete understanding of the variation in production of antigens at different sites of infection and at different times during the infectious process, particularly as manifest by clinical isolates. This review discusses many of the strategies pursued to date in the quest for an effective vaccine for P. aeruginosa. A diagrammatic representation of the bacterium is presented in (Fig. 1) and helps to categorize the various P. aeruginosa antigens that have been used as vaccine targets.

Keywords

Cystic Fibrosis Pseudomonas Aeruginosa Cystic Fibrosis Transmembrane Conductance Regulator Outer Membrane Protein Protective Efficacy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Gregory P. Priebe
  • Gerald B. Pier

There are no affiliations available

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