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Dynamism of Postsynaptic Proteins as the Mechanism of Synaptic Plasticity

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Excitatory-Inhibitory Balance

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Abstract

At excitatory synapses of the vertebrate central nervous system, the neuronal information is transmitted via glutamate which is released from presynaptic terminals and opens postsynaptic cation channels integrated in glutamate receptor proteins. This transmission is not static, but rather is dynamically regulated in both a positive and negative manner by its own activity level as well as by interactions with other synaptic inputs. Such regulation is collectively called synaptic plasticity. After the discovery of synaptic plasticity, intensive work over the past three decades has shown that excitatory synapses in the central nervous system exhibit a remarkable degree of plasticity. Most importantly, growing evidence suggests that synaptic plasticity is the molecular/cellular basis of learning and memory.

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Authors and Affiliations

  1. RIKEN-MIT Neuroscience Research Center, The Picower Center for Learning and Memory, Department of Brain and Cognitive Science, Massachusetts Institute of Technology, E18-270, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA

    Kensuke Futai & Yasunori Hayashi

  2. Laboratory for Neural Architecture, Brain Science Institute,RIKEN, Wako, Saitama, 351-0198, Japan

    Kensuke Futai

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  1. Kensuke Futai
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  2. Yasunori Hayashi
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  1. RIKEN Brain Science Institute, Wako-shi, Japan

    Takao K. Hensch  & Michela Fagiolini  & 

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Futai, K., Hayashi, Y. (2003). Dynamism of Postsynaptic Proteins as the Mechanism of Synaptic Plasticity. In: Hensch, T.K., Fagiolini, M. (eds) Excitatory-Inhibitory Balance. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0039-1_3

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  • DOI: https://doi.org/10.1007/978-1-4615-0039-1_3

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