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GABAA Receptor Subtypes: Memory Function and Neurological Disorders

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Excitatory-Inhibitory Balance

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Abstract

GABA is the main inhibitory neurotransmitter in the vertebrate CNS and it modulates every aspect of brain function. On the molecular level, the action of GABA is mediated by ionotropic (GABAA)1 and metabotropic (GABAB)2 receptors, which are ubiquitously expressed in developing and adult brain. The significance of GABAA receptor-mediated neurotransmission is underscored by the multiple neurological and psychiatric diseases for which alterations in the GABAergic system have been postulated, including epilepsy3–5, Huntington’s disease6, Angelman syndrome7, autism8, 9, anxiety disorders10, bipolar disorders, schizophrenia11–13, and alcohol use disorders14. In particular, GABAA receptors represent a major site of action for clinically important drugs, including benzodiazepines and barbiturates, some general anesthetics such as halothane, etomidate and propofol, as well as ethanol15–18.

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References

  1. Barnard, E.A., Skolnick, P., Olsen, R.W., Mohler, H., Sieghart, W., Biggio, G., Braestrup, C., Bateson, A.N. and Langer, S.Z., Pharmacol. Rev. 50, 291 (1998).

    PubMed  CAS  Google Scholar 

  2. Bowery, N.G., Bettler, B., Froestl, W., Gllagher, J.P., Marshall, F., Raiteri, M., Bonner, T.I. and Enna, S.J.,Pharmacol. Rev. 54, 247 (2002).

    PubMed  CAS  Google Scholar 

  3. Duncan, J.S., Rev. Neurol. 155, 482 (1999).

    PubMed  CAS  Google Scholar 

  4. Olsen, R.W., DeLorey, T.M., Gordey, M. and Kang, M.H., Adv. Neurol. 79,499 (1999).

    PubMed  CAS  Google Scholar 

  5. Coulter, D.A., Int. Rev. Neurobiol. 45, 237 (2001).

    PubMed  CAS  Google Scholar 

  6. Kunig, G., Leenders, K.L., Sanchez-Pernaute, R., Antonini, A., Vontobel, P., Verhagen, A. and Gunther, I., Ann. Neurol. 47, 644 (2000).

    PubMed  CAS  Google Scholar 

  7. DeLorey, T.M., Handforth, A., Anagnostaras, S.G., Homanics, G.E., Minassian, B.A., Asatourian, A., Fanselow, M.S., Delgado-Escueta, A., Ellison, G.D. and Olsen, R.W., J. Neurosci. 18, 8505 (1998).

    PubMed  CAS  Google Scholar 

  8. Fatemi, S.H., Halt, A.R., Stary, J.M., Kanodia, R., Schulz, S.C. and Realmuto, G.R., Biol. Psychiatry 52, 805 (2002).

    PubMed  CAS  Google Scholar 

  9. Buxbaum, J.D., Silverman, J.M., Smith, C.J., Greenberg, D.A., Kilifarski, M., Reichert, J., Cook, E.H., Fang, Y., Song, C.Y. and Vitale, R., Mol. Psychiatry 7, 311 (2002).

    PubMed  CAS  Google Scholar 

  10. Malizia, A.L., J. Psychopharmacol. 13, 372 (1999).

    PubMed  CAS  Google Scholar 

  11. Nutt, D.J. and Malizia, A.L., Brit. J. Psychiat. 179, 390 (2001).

    PubMed  CAS  Google Scholar 

  12. Blum, B.P. and Mann, J.J., Int. J. Neuropsychopharm. 5, 159 (2002).

    CAS  Google Scholar 

  13. Lewis, D.A., Brain Res. Rev. 31, 270 (2000).

    PubMed  CAS  Google Scholar 

  14. Morrow, A.L., VanDoren, M.J., Penland, S.N. and Matthews, D.B., Brain Res. Rev. 37, 98 (2001).

    PubMed  CAS  Google Scholar 

  15. Sieghart, W., Pharmacol. Rev. 47, 181 (1995).

    PubMed  CAS  Google Scholar 

  16. Dilger, J.P., Br. J. Anaest. 89,41 (2002).

    CAS  Google Scholar 

  17. Mohler, H., Fritschy, J.M. and Rudolph, U., J. Pharm. Exp. Ther. 300, 2 (2002).

    CAS  Google Scholar 

  18. Grobin, A.C., Matthews, D.B., Devaud, L.L. and Morrow, A.L., Psychopharmacohgy. 139, 2 (1998).

    CAS  Google Scholar 

  19. Unwin, N., Neuron 10 Suppl., 31 (1993).

    Google Scholar 

  20. Barnard, E.A., in: Pharmacology of GABA and glycine neurotransmission, Handbook Expt. Pharmacol., vol. I50, edited by H. Mohler, (Springer-Verlag, Berlin, 2001) p. 79.

    Google Scholar 

  21. Whiting, P.J., Neurochem. Int. 34, 387 (1999).

    PubMed  CAS  Google Scholar 

  22. Knight, A.R., Stephenson, F.A., Tallman, J.F. and Ramabahdran, T.V., Recept. Channels 7, 213 (2000).

    PubMed  CAS  Google Scholar 

  23. Baumann, S.W., Baur, R. and Sigel, E., J. Biol. Chem. 276, 36275 (2001).

    PubMed  CAS  Google Scholar 

  24. Klausberger, T., Sarto, I., Ehya, N., Fuchs, K., Furtmuller, R., Mayer, B., Huck, S. and Sieghart, W., J.Neurosci. 21, 9124(2001).

    PubMed  CAS  Google Scholar 

  25. Farrar, S.J., Whiting, P.J., Bonnert, T.P. and McKernan, R.M., J. Biol. Chem. 274, 10100 (1999).

    PubMed  CAS  Google Scholar 

  26. Bormann, J., Trends Pharmacol. Sci. 21, 16 (2000).

    PubMed  CAS  Google Scholar 

  27. Benson, J.A., Low, K., Keist, R., Mohler, H. and Rudolph, U., FEBS Lett. 431, 400 (1998).

    PubMed  CAS  Google Scholar 

  28. Wingrove, P.B., Safo, P., Wheat, L., Thompson, S.A., Wafford, K.A. and Whiting, P.J., Eur. J. Pharmacol 437, 31(2002).

    PubMed  CAS  Google Scholar 

  29. Mohler, H., Fritschy, J.M., Luscher, B., Rudolph, U., Benson, J. and Benke, D., in: Ion channels, vol. 4, edited by T. Narahashi, (Plenum Press, New York, 1996) p. 89.

    Google Scholar 

  30. Lambert, J.J., Belelli, D., Harney, S.C., Peters, J.A. and Frenguelli, B.G., Brain Res. Rev. 37, 68 (2001).

    PubMed  CAS  Google Scholar 

  31. Wohlfarth, K.M., Bianchi, M.T. and Macdonald, R.L., J. Neurosci. 22, 1541 (2002).

    PubMed  CAS  Google Scholar 

  32. Adkins, C.E., Pillai, G.V., Kerby, J., Bonnert, T.P., Haldon, C., McKernan, R.M., Gonzalez, J.E., Oades, K., Whiting, P.J. and Simpson, P.B.,J. Biol. Chem. 276, 38934 (2001).

    PubMed  CAS  Google Scholar 

  33. Sigel, E. and Dodd, R.H., Drugs Future 26, 1191 (2001).

    CAS  Google Scholar 

  34. Collins, I., Moyes, C., Davey, W.B., Rowley, M., Bromidge, F.A., Quirk, K., Atack, J.R., McKernan, R.M., Thompson, S.A., Wafford, K., Dawson, G.R., Pike, A., Sohal, B., Tsou, N.N., Ball, R.G. and Castro, J.L., J. Med. Chem. 45, 1887 (2002).

    PubMed  CAS  Google Scholar 

  35. Selleri, S., Bruni, F., Costagli, C., Costanzo, A., Guerrini, G., Ciciani, G., Gratteri, P., Bonaccini, C., Malmberg Aiello, P., Besnard, F., Renard, S., Costa, B. and Martini, C., J. Med. Chem. 46, 310 (2003).

    PubMed  CAS  Google Scholar 

  36. Griebel, G., Perrault, G., Simiand, J., Cohen, C., Granger, P., Decobert, M., Françon, D., Avenet, P., Depoortere, H., Tan, S., Oblin, A., Schoemaker, H., Evanno, Y., Sevrin, M., George, P. and Scatton, B., J. Pharmacol. Exp. Ther. 298, 753 (2001).

    PubMed  CAS  Google Scholar 

  37. Verdoorn, T.A., Draguhn, A., Ymer, S., Seeburg, P.H. and Sakmann, B., Neuron 4, 919 (1990).

    PubMed  CAS  Google Scholar 

  38. Hutcheon, B., Morley, P. and Poulter, M.O., J. Physiol. 522, 3 (2000).

    PubMed  CAS  Google Scholar 

  39. Devor, A., Fritschy, J.M. and Yarom, Y., J. Neurophysiol. 85,1686 (2001).

    PubMed  CAS  Google Scholar 

  40. Burgard, E.C., Tietz, E.I., Neelands, T.R. and Macdonald, R.L., Mol. Pharmacol. 50, 119 (1996).

    PubMed  CAS  Google Scholar 

  41. Fisher, J.L. and Macdonald, R.L., J. Physiol. 505, 283 (1997).

    PubMed  CAS  Google Scholar 

  42. Mihalek, R.M., Bowers, B.J., Wehner, J.M., Kralic, J.E., VanDoren, M.J., Morrow, A.L. and Homanics, G.E., Alcohol. Clin. Exp. Res. 25, 1708 (2001).

    PubMed  CAS  Google Scholar 

  43. Spigelman, I., Li, Z., Banerjee, P.K., Mihalek, R.M., Homanics, G.E. and Olsen, R.W., Epilepsia 43, 3 (2002).

    PubMed  CAS  Google Scholar 

  44. Porcello, D.M., Huntsman, M.M., Mihalek, R.M., Homanics, G.E. and Huguenard, J.R., J. Neurophysiology 89,1378 (2003).

    CAS  Google Scholar 

  45. Schwarzer, C., Berresheim, U., Pirker, S., Wieselthaler, A., Fuchs, K., Sieghart, W. and Sperk, G., J. Comp.Neurol. 433, 526 (2001).

    PubMed  CAS  Google Scholar 

  46. Waldvogel, H.J., Fritschy, J.M., Mohler, H. and Faull, R.L.M., J. Comp. Neurol. 397, 297 (1998).

    PubMed  CAS  Google Scholar 

  47. Pirker, S., Schwarzer, C., Wieselthaler, A., Sieghart, W. and Sperk, G., Neurosci. 101, 815 (2000).

    CAS  Google Scholar 

  48. Fritschy, J.M. and Mohler, H., J. Comp. Neurol. 359, 154 (1995).

    PubMed  CAS  Google Scholar 

  49. Gao, B., Fritschy, J.M., Benke, D. and Mohler, H., Neurosci. 54, 881 (1993).

    CAS  Google Scholar 

  50. Huntsman, M.M., Porcello, D.M., Homanics, G.E., DeLorey, T.M. and Huguenard, J.R., Science 283, 541 (1999).

    PubMed  CAS  Google Scholar 

  51. Sieghart, W., Fuchs, K., Tretter, V., Ebert, V., Jechlinger, M., Hoger, H. and Adamiker, D., Neurochem. Int. 34, 379 (1999).

    PubMed  CAS  Google Scholar 

  52. Rudolph, U., Crestani, F. and Mohler, H., Trends Pharmacol. Sci. 22, 188 (2001).

    PubMed  CAS  Google Scholar 

  53. Low, K., Crestani, F., Keist, R., Benke, D., Brünig, I., Benson, J.A., Fritschy, J.M., Rulicke, T., Bluethmann, H., Mohler, H. and Rudolph, U., Science 290, 131 (2000).

    PubMed  CAS  Google Scholar 

  54. Rudolph, U.,Crestani, F., Benke, D., Brünig, I., Benson, J., Fritschy, J.M., Martin, J.R., Bluethmann, H. and Mohler, H., Nature 401, 796 (1999).

    PubMed  CAS  Google Scholar 

  55. McKernan, R.M., Rosahl, T.W., Reynolds, D.S., Sur, C., Wafford, K.A., Atack, J.R., Farrar, S., Myers, J., Cook, G., Ferris, P., Garrett, L., Bristow, L., Marshall, G., Macaulay, A., Brown, N., Howell, O., Moore, K.W., Carling, R.W., Street, L.J., Castro, J.L., Ragan, C.I., Dawson, G.R. and Whiting, P.J., Nature Neurosci. 3, 587 (2000).

    PubMed  CAS  Google Scholar 

  56. Crestani, F., Martin, J.R., Mohler, H. and Rudolph, U., Brit. J. Pharmacol. 131, 1251 (2000).

    CAS  Google Scholar 

  57. Crestani, F., Assandri, R., Täuber, M., Martin, J.R. and Rudolph, U., Neuropharmacol. 43, 679 (2002).

    CAS  Google Scholar 

  58. Nusser, Z., Sieghart, W., Benke, D., Fritschy, J.M. and Somogyi, P., Proc. Natl Acad. Sci. USA 93, 11939 (1996).

    PubMed  CAS  Google Scholar 

  59. Fritschy, J.M., Weinmann, O., Wenzel, A. and Benke, D., J. Comp. Neurol. 390, 194 (1998).

    PubMed  CAS  Google Scholar 

  60. Brünig, I., Scotti, E., Sidler, C. and Fritschy, J.M., J.Comp. Neurol. 443, 43 (2002).

    PubMed  Google Scholar 

  61. Crestani, F., Keist, R., Fritschy, J.M., Benke, D., Vogt, K., Prut, L., Bluethmann, H., Mohler, H. and Rudolph, U., Proc. Natl. Acad. Sci. USA 99, 8980 (2002).

    PubMed  CAS  Google Scholar 

  62. Klausberger, T., Roberts, J.D. and Somogyi, P., J. Neurosci. 22, 2513 (2002).

    PubMed  CAS  Google Scholar 

  63. Nyiri, G., Freund, T.F. and Somogyi, P., Eur. J. Neurosci. 13, 428 (2001).

    PubMed  CAS  Google Scholar 

  64. Freund, T.F. and Buzsaki, G., Hippocampus 6, 345 (1996).

    CAS  Google Scholar 

  65. Katona, I., Rancz, E.A., Acsady, L., Ledent, C., Mackie, K., Hajos, N. and Freund, T.F., J. Neurosci. 21, 9506 (2001).

    PubMed  CAS  Google Scholar 

  66. Katona, I., Sperlágh, B., Sík, A., Käfalvi, A., Vizi, E.S., Mackie, K. and Freund, T.F., J. Neurosci. 19, 4544 (1999).

    PubMed  CAS  Google Scholar 

  67. Wilson, R.I., Kunos, G. and Nicoll, R.A., Neuron 31, 453 (2001).

    PubMed  CAS  Google Scholar 

  68. Llano, I., Leresche, N. and Marty, A., Neuron 6, 565 (1991).

    PubMed  CAS  Google Scholar 

  69. Pitler, T.A. and Alger, B.E., J. Neurosci. 12, 4122 (1992).

    PubMed  CAS  Google Scholar 

  70. Wilson, R.I. and Nicoll, R.A., Science 296, 678 (2002).

    PubMed  CAS  Google Scholar 

  71. Somogyi, P., Takagi, H., Richards, J.G. and Mohler, H., J. Neurosci. 9, 2197 (1989).

    PubMed  CAS  Google Scholar 

  72. Sassoè-Pognetto, M., Panzanelli, P., Sieghart, W. and Fritschy, J.M., J. Comp. Neurol. 420, 481 (2000).

    PubMed  Google Scholar 

  73. Nusser, Z., Roberts, J.D.B., Baude, A., Richards, J.G., Sieghart, W. and Somogyi, P., Eur. J. Neurosci. 7, 630 (1995).

    PubMed  CAS  Google Scholar 

  74. Somogyi, P., Fritschy, J.M., Benke, D., Roberts, J.D.B. and Sieghart, W., Neuropharmacology 35, 1425 (1996).

    PubMed  CAS  Google Scholar 

  75. Waldvogel, H.J., Kubota, Y., Trevallyan, S.C., Kawaguchi, Y., Fritschy, J.M., Mohler, H. and Faull, R.L., Neurosci. 80, 775 (1997).

    CAS  Google Scholar 

  76. Somogyi, P., in: Neural mechanisms of visual perception, edited by D.K.T. Lam and C.D. Gilbert, (Portfolio Publishing Co, Houston, 1989) p. 35.

    Google Scholar 

  77. Giustetto, M., Kirsch, J., Fritschy, J.M., Cantino, D. and Sassoè-Pognetto, M., J. Comp. Neurol. 395, 231 (1998).

    PubMed  CAS  Google Scholar 

  78. Nusser, Z., Sieghart, W., Stephenson, F.A. and Somogyi, P., J. Neurosci. 16, 103 (1996).

    PubMed  CAS  Google Scholar 

  79. Nusser, Z., Sieghart, W. and Somogyi, P., J. Neurosci. 18, 1693 (1998).

    PubMed  CAS  Google Scholar 

  80. Nusser, Z., Ahmad, Z., Tretter, V., Fuchs, K., Wisden, W., Seighart, W. and Somogyi, P., Eur. J. Neurosci. 11,1685(1999).

    PubMed  CAS  Google Scholar 

  81. Mody, I., Neurochem. Res. 26, 907 (2001).

    PubMed  CAS  Google Scholar 

  82. Koulen, P., Brandstatter, J.H., Enz, R., Bormann, J. and Wassle, H., Eur. J. Neurosci. 10, 115 (1998).

    PubMed  CAS  Google Scholar 

  83. Macdonald, R.L. and Olsen, R.W., Annu. Rev. Neurosci. 17, 569 (1994).

    PubMed  CAS  Google Scholar 

  84. Mohler, H., in: Pharmacology of GABA and Glycine Neurotransmission, Handbook Expt. Pharmacol, vol. 150, edited by H. Mohler, (Springer-Verlag, Berlin Heidelberg, 2000) p. 101.

    Google Scholar 

  85. Whiting, P.J., Bonnert, T.P., McKernan, R.M., Farrar, S., Le Bourdelles, B., Heavens, R.P., Smith, D.W., Hewson, L., Rigby, M.R., Sirinathsinghji, D.J., Thompson, S.A. and Wafford, K.A., Ann. NY Acad. Sci. 868, 645 (1999).

    PubMed  CAS  Google Scholar 

  86. Brun, V.H., Otnaess, M.K., Molden, S., Steffenach, H.A., Witter, M.P., Moser, M.B. and Moser, E.I., Science 296, 2243 (2002).

    PubMed  CAS  Google Scholar 

  87. Engel, A.K., Fries, P. and Singer, W., Nature Rev. Neurosci. 2,704 (2001).

    CAS  Google Scholar 

  88. Harris, K.D., Henze, D.A., Hirase, H., Leinekugel, X., Dragoi, G., Czurko, A. and Buzsaki, G., Nature 417, 738 (2002).

    PubMed  CAS  Google Scholar 

  89. Metha, M.R., Lee, A.K. and Wilson, M.A., Nature 417, 741 (2002).

    Google Scholar 

  90. O’Keefe, J. and Nadel, L., The hippocampus as a cognitive map, Clarendon Press, Oxford (1978).

    Google Scholar 

  91. O’Keefe, J. and Recce, M.L., Hippocampus 3, 317 (1993).

    Google Scholar 

  92. Paulsen, O. and Moser, E.I., Trends Neurosci. 21, 273 (1998).

    PubMed  CAS  Google Scholar 

  93. Skaggs, W.E., McNaughton, B.L., Wilson, M.A. and Barnes, C.A., Hippocampus 6, 149 (1996).

    PubMed  CAS  Google Scholar 

  94. Traub, R.D., Draguhn, A., Whittington, M.A., Baldeweg, T., Bibbig, A., Buhl, E.H. and Schmitz, D., Rev. Neurosci. 13, 1 (2002).

    PubMed  Google Scholar 

  95. Buzsaki, G. and Chrobak, J.J., Curr. Opin. Neurobiol. 5, 504 (1995).

    PubMed  CAS  Google Scholar 

  96. Miles, R., Science 287, 244 (2000).

    PubMed  CAS  Google Scholar 

  97. Klausberger, T., Magill, P.J., Marton, L.F., Roberts, J.D.B., Cobden, P.M., Buzsaki, G. and Somogyi, P., Nature 421, 844 (2003).

    PubMed  CAS  Google Scholar 

  98. Burgess, N., Maguire, E.A. and O’Keefe, J., Neuron 35, 625 (2002).

    PubMed  CAS  Google Scholar 

  99. Csicsvari, J., Hirase, H., Czurko, A., Mamiya, A. and Buzsaki, G., J. Neurosci. 19, 274 (1999).

    PubMed  CAS  Google Scholar 

  100. Maccaferri, G., Roberts, J.D.B., Szucs, P., Cottingham, C.A. and Somogyi, P., J. Physiol. 524, 91 (2000).

    PubMed  CAS  Google Scholar 

  101. Morris, R.G.M., J. Neurosci. 9, 3040 (1989).

    PubMed  CAS  Google Scholar 

  102. Morris, R.G.M., Anderson, A., Lynch, G.S. and Baudry, M., Nature 319, 774 (1986).

    PubMed  CAS  Google Scholar 

  103. Davis, S., Butcher, S.P. and Morris, R.G.M., J. Neurosci. 12, 21 (1992).

    PubMed  CAS  Google Scholar 

  104. McHugh, T.J., Blum, K., Tsien, J.Z., Tonegawa, S. and Wilson, M.A., Cell 87, 1339 (1996).

    PubMed  CAS  Google Scholar 

  105. Tsien, J.Z., Huerta, P.T. and Tonegawa, S., Cell 87,1327 (1996).

    PubMed  CAS  Google Scholar 

  106. Huerta, P.T., Sun, L.D., Wilson, M.A. and Tonegawa, S., Neuron 25, 473 (2000).

    PubMed  CAS  Google Scholar 

  107. Nakazawa, K., Quirk, M.C., Chitwood, R.A., Watanabe, M., Yeckel, M.F., Sun, L.D., Kato, A., Carr, C.A., Johnston, D., Wilson, M.A. and Tonegawa, S., Science 297, 211 (2002).

    PubMed  CAS  Google Scholar 

  108. Tang, Y.P., Shimizu, E., Dube, G.R., Rampon, C., Kerchner, G.A., Zhuo, M., Liu, G. and Tsien, J.Z., Nature 401, 63 (1999).

    PubMed  CAS  Google Scholar 

  109. Gupta, A., Wang, Y. and Markram, H., Science 287, 273 (2000).

    PubMed  CAS  Google Scholar 

  110. Fricker, D. and Miles, R., Neuron 32, 771 (2001).

    PubMed  CAS  Google Scholar 

  111. Collinson, N., Kuenzi, F.M., Jarolimek, W., Maubach, K.A., Cothliff, R., Sur, C., Smith, A.D., Otu, F.M., Howell, O., Atack, J.R., McKernan, R.M., Seabrook, G.R., Dawson, G.R., Whiting, P.J. and Rosahl, T.W., J. Neurosci. 22, 5572 (2002).

    PubMed  CAS  Google Scholar 

  112. Whiting, P.J., Drug Discov. Today in press (2003).

    Google Scholar 

  113. Alger, B.E. and LeBeau, F.E.N., in: Pharmacology of GABA and glycine neurotransmission. Handbook Expt. Pharmacol. vol. 150, edited by H. Möhler, (Springer, New York, 2001) p. 3.

    Google Scholar 

  114. Nusser, Z. and Mody, I., J. Neurophysiol. 87, 2624 (2002).

    PubMed  CAS  Google Scholar 

  115. Cobb, S.R., Buhl, E.H., Halasy, K., Paulsen, O. and Somogyi, P., Nature 378, 75 (1995).

    PubMed  CAS  Google Scholar 

  116. Whittington, M.A., Traub, R.D. and Jefferys, J.G.R., Nature 373, 612 (1995).

    PubMed  CAS  Google Scholar 

  117. Wallenstein, G., Eichenbaum, H. and Hasselmo, M., Trends in Neurosci 21, 317 (1998).

    CAS  Google Scholar 

  118. Tamas, G., Buhl, E.H., Lorincz, A. and Somogyi, P., Nature Neurosci. 3, 366 (2000).

    PubMed  CAS  Google Scholar 

  119. Galarretta, M. and Hestrin, S., Nature 402, 72 (1999).

    Google Scholar 

  120. Gibson, J.R., Beierlein, M. and Connors, B.W., Nature 402, 75 (1999).

    PubMed  CAS  Google Scholar 

  121. Brickley, S.G., Cull-Candy, S.G. and Farrant, M., J. Physiol. 497, 753 (1996).

    PubMed  CAS  Google Scholar 

  122. Faull, R.L.M., Waldvogel, H.J., Nicholson, L.F.B. and Synek, B.J.L., Prog. Brain Res. 99, 105 (1993).

    PubMed  CAS  Google Scholar 

  123. Brickell, K.L., Nicholson, L.F.B., Waldvogel, H.J. and Faull, R.L.M., J. Chem. Neuroanat. 17, 75 (1999).

    PubMed  CAS  Google Scholar 

  124. Fujiyama, F., Stephenson, F.A. and Bolam, J.P., Eur. J. Neurosci. 15, 1961 (2002).

    PubMed  Google Scholar 

  125. Baulac, S., Huberfeld, G., Gourfinkel-An, I., Mitropoulou, G., Beranger, A., Prud’homme, J.F., Baulac, M., Brice, A., Bruzzone, R. and LeGuern, E., Nature Genet. 28, 46 (2001).

    PubMed  CAS  Google Scholar 

  126. Wallace, R., Marini, C., Petrou, S., Harkin, L.A., Bowser, D.N., Panchal, R.G., Williams, D.A., Sutherland, G.R., Mulley, J.C., Scheffer, I.E. and Berkovic, S.F., Nature Genet. 28, 49 (2001).

    PubMed  CAS  Google Scholar 

  127. Marini, C., Harkin, L.A., Wallace, R.H., Mulley, J.C., Scheffer, I.E. and Berkovic, S.F., Brain 126, 230 (2003).

    PubMed  Google Scholar 

  128. Bowser, D.N., Wagner, D.A., Czajkowski, C., Cromer, B.A., Parker, M.W., Wallace, R.H., Harkin, L.A., Mulley, J.C., Marini, C., Berkovic, S.F., Williams, D.a., Jones, M.V. and Petrou, S., Proc. Natl. Acad. Sci. USA 99, 15170 (2002).

    PubMed  CAS  Google Scholar 

  129. Kananura, C., Haug, K., Sander, T., Runge, U., Gu, W., Hallmann, K., Rebstock, J., Heils, A. and Steinlein, O.K., Arch. Neurol. 59, 1137 (2002).

    PubMed  Google Scholar 

  130. Harkin, L.A., Bowser, D.N., Dibbens, L.M., Singh, R., Phillips, F., Wallace, R.H., Richards, M.C., Williams, D.A., Mulley, J.C., Berkovic, S.F., Scheffer, I.E. and Petrou, S., Amer. J. Hum. Genet. 70, 530 (2002).

    PubMed  CAS  Google Scholar 

  131. Cossette, P., Liu, L., Brisebois, K., Dong, H., Lortie, A., Vanasse, M., Saint-Hilaire, J.M., Carmant, L., Verner, A., Lu, W.Y., Wang, Y.T. and Rouleau, G.A., Nature Genet. 31,184 (2002).

    PubMed  CAS  Google Scholar 

  132. Gambardella, A., Manna, I., Labate, A., Chifari, R., La Russa, A., Serra, P., Cittadella, R., Bonavita, S., Andreoli, V., LePiane, E., Sasanelli, F., Di Costanzo, A., Zappia, M., Tedeschi, G., Aguglia, U. and Quattrone, A., Neurol. 60, 560 (2003).

    CAS  Google Scholar 

  133. Jones-Davis, D.M. and Macdonald, R.L., Cur. Opin. Pharmacol 3, 12 (2003).

    CAS  Google Scholar 

  134. Savic, I., Roland, P., Sedvall, G., Persson, A., Pauli, S. and Widen, L., Lancet 2, 863 (1988).

    PubMed  CAS  Google Scholar 

  135. Debets, R.M., Sadzot, B., van Isselt, J.W., Brekelmans, G.J.F., Meiners, L.C., van Huffelen, A.C., Franck, G. and van Veelen, C.W.M., J. Neurol. 62, 141 (1997).

    CAS  Google Scholar 

  136. Hammers, A., Koepp, M.J., Hurlemann, R., Thom, M., Richardson, M.P., Brooks, D.J. and Duncan, J.S., Brain 125, 2257 (2002).

    PubMed  CAS  Google Scholar 

  137. Sata, Y., Matsuda, H., Mihara, T., Aihara, M., Yagi, K. and Yonekura, Y., Epilepsia 43,1039 (2002).

    PubMed  CAS  Google Scholar 

  138. Loup, F., Wieser, H.G., Yonekawa, Y., Aguzzi, A. and Fritschy, J.M., J. Neurosci. 20, 5401 (2000).

    PubMed  CAS  Google Scholar 

  139. Cohen, I., Navarro, V., Clemenceau, S., Baulac, M. and Miles, R., Science 298, 1418 (2002).

    PubMed  CAS  Google Scholar 

  140. Brooks-Kayal, A.R., Shumate, M.D., Jin, H., Rikhter, T.Y. and Coulter, D.A., Nature Med. 4, 1166 (1998).

    PubMed  CAS  Google Scholar 

  141. Schwarzer, C., Tsunashima, K., Wanzenbock, C., Fuchs, K., Sieghart, W. and Sperk, G., Neurosci. 80, 1001 (1997).

    CAS  Google Scholar 

  142. Fritschy, J.M., Kiener, T., Bouilleret, V. and Loup, F., Neurochem. Int. 34, 435 (1999).

    PubMed  CAS  Google Scholar 

  143. Riban, V., Bouilleret, V., Pham-Lè, B.T., Fritschy, J.M., Marescaux, C. and Depaulis, A., Neurosci. 112,101 (2002).

    CAS  Google Scholar 

  144. Bouilleret, V., Ridoux, V., Depaulis, A., Marescaux, C., Nehlig, A. and Le Gal La Salle, G., Neurosci. 89, 717 (1999).

    CAS  Google Scholar 

  145. Bouilleret, V., Loup, F., Kiener, T., Marescaux, C. and Fritschy, J.M., Hippocampus 10, 305 (2000).

    PubMed  CAS  Google Scholar 

  146. Knuesel, I., Zuellig, R.A., Schaub, M.C. and Fritschy, J.M., Eur. J. Neurosci. 13,1113 (2001).

    PubMed  CAS  Google Scholar 

  147. Benes, F.M. and Berretta, S., Neuropsychopharmacol. 25, 1 (2001).

    CAS  Google Scholar 

  148. Volk, D.W. and Lewis, D.A., Physiol. Behav. 77, 501 (2002).

    PubMed  CAS  Google Scholar 

  149. Heckers, S. and Konradi, C., J. Neural Transm. 109, 891 (2002).

    PubMed  CAS  Google Scholar 

  150. Heckers, S., Stone, D., Walsh, J., Shick, J., Koul, P. and Benes, F.M., Arch. Gen. Psychiatry 59, 521 (2002).

    PubMed  CAS  Google Scholar 

  151. Cotter, D., Landau, S., Beasley, C., Stevenson, R., Chana, G., Macmillan, L. and Everall, I., Biol. Psychiatry 51, 377 (2002).

    PubMed  CAS  Google Scholar 

  152. Woo, T.U., Whitehead, R.E., Melchitzky, D.S. and Lewis, D.A., Proc. Natl. Acad. Sci. USA 95, 5341 (1998).

    PubMed  CAS  Google Scholar 

  153. Volk, D.W., Pierri, J.N., Fritschy, J.M., Auh, S., Sampson, A.R. and Lewis, D.A., Cereb. Cortex. 12, 1063 (2002).

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Institute of Pharmacology and Toxicology, Univ. of Zurich, Switzerland

    Jean-Marc Fritschy, Florence Crestani, Uwe Rudolph & Hanns Möhler

  2. Dept. of Applied Biosciences, Swiss Federal Institute of Technology (ETH), 8057, Zurich, Switzerland

    Hanns Möhler

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  1. Jean-Marc Fritschy
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  2. Florence Crestani
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  4. Hanns Möhler
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  1. RIKEN Brain Science Institute, Wako-shi, Japan

    Takao K. Hensch  & Michela Fagiolini  & 

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Fritschy, JM., Crestani, F., Rudolph, U., Möhler, H. (2003). GABAA Receptor Subtypes: Memory Function and Neurological Disorders. In: Hensch, T.K., Fagiolini, M. (eds) Excitatory-Inhibitory Balance. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0039-1_14

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