Adult Neurogenesis Controls Excitatory-Inhibitory Balance in the Olfactory Bulb
In the cortex, networks of inhibitory interneurons play a crucial role in the modulation of the electrical activity patterns of the principal neurons known as projecting (glutamatergic) neurons. Inhibitory interneurons containing □-aminobutyric acid (GABA), with distinct connectivities and neurochemical features, carry out specific functions within cortical networks. They govern, for instance, the activity of the profusely interconnected ensembles of projecting neurons, and are responsible for the precise timing of individual principal cell discharges in relation to the emergent behavior of the entire cell assembly. Today, one of the central issue in developmental neurobiology is the need to characterize how both projecting neurons and the various interneurons migrate along precise pathways to find the correct sites for their final differentiation and integration. This highly temporally and spatially orchestrated migration is essential for proper brain development and function.
KeywordsGranule Cell Olfactory Bulb Adult Neurogenesis Local Field Potential Mitral Cell
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