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Molluskan Ocular Pacemakers: Lessons Learned

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Book cover The Retina and Circadian Rhythms

Part of the book series: Springer Series in Vision Research ((SSVR,volume 1))

Abstract

Invertebrate models have proved invaluable in understanding of fundamental properties of the nervous system including the ionic basis of the resting potential, impulse production, synaptic transmission, and the cellular basis of learning and memory. Invertebrate models have also provided important insights into the cellular mechanisms underlying circadian rhythms. Study of the retinae of several opisthobranch mollusks, which contain circadian clocks, has provided lasting insights into the cellular/molecular basis of biological timing. Key “lessons” from the molluskan retina include the cell-autonomous nature of neuronal clocks, the mechanisms underlying coupling within multi-oscillator ensembles, and the biochemical/ionic mechanisms involved in synchronization of the clock by environmental timing cycles. Much of what was learned from molluskan retinae remains highly relevant to study of mammalian circadian system.

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Authors and Affiliations

  1. Laboratory of Circadian and Sleep Medicine, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA, 90024, USA

    Gene D. Block Ph.D. & Christopher S. Colwell Ph.D.

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  1. Gene D. Block Ph.D.
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  2. Christopher S. Colwell Ph.D.
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Correspondence to Gene D. Block Ph.D. .

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Editors and Affiliations

  1. Morehouse School of Medicine, Atlanta, Georgia, USA

    Gianluca Tosini

  2. Emory University, Atlanta, Georgia, USA

    P. Michael Iuvone

  3. Vanderbilt University Medical Center, Nashville, Tennessee, USA

    Douglas G. McMahon

  4. The University of Western Australia, Crawley, West Australia, Australia

    Shaun P. Collin

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Block, G.D., Colwell, C.S. (2014). Molluskan Ocular Pacemakers: Lessons Learned. In: Tosini, G., Iuvone, P., McMahon, D., Collin, S. (eds) The Retina and Circadian Rhythms. Springer Series in Vision Research, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9613-7_11

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