Chitin, Chitosan, and Their Derivatives Against Oxidative Stress and Inflammation, and Some Applications



Chitin, a polymer of N-acetylglucosamine (GlcNAc), (1→4)-linked 2-acetamido-2-deoxy-β-D-glucan, is widely distributed among invertebrates and crustaceans as structural material in their exoskeletons and fungal cell walls. Chitin and its derivatives have important biological properties with potential for a wide variety of applications, such as immunostimulatory, antioxidant, anti-inflammatory, antimicrobial, anticancer, anticholesteremic, anticoagulant, and wound-healing agents. However, chitin is an insoluble polymer in water, and this property is the major limiting factor for its utilization in living systems. Up until now, there have been many reports on the biological activities of derivatives of chitin, which are easily soluble in water, can be used in various applications. Especially, scientists have synthesized many novel derivatives that have activity against oxidative stress and inflammation. Therefore, this chapter reviews the knowledge of some synthetic and productive methods of several derivatives of chitin, chitosan, and, moreover, their antioxidant and anti-inflammation effects as well as potential applications are also presented.


Nitric Oxide Cellular Reactive Oxygen Species Sulfated Glucosamine Accelerate Wound Healing Carboxymethyl Chitosan 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The author wishes to acknowledge Prof. Se-Kwon Kim, Prof. Moo-Moo Kim, and Vietnam’s National Foundation for Science and Technology Development (NAFOSTED) for the support provided through research grant 106.05.2011.36.


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© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of Biochemistry, Faculty of BiologyUniversity of Science, Vietnam National University, Ho Chi Minh City (VNU-HCMC)Ho Chi Minh CityVietnam

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