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Periodontitis and Oxidative Stress: Human Studies

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Studies on Periodontal Disease

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Abstract

The knowledge of the pathogenic effects of oxidative stress in the periodontium, discussed in previous chapters, has stimulated several lines of research into the associations between redox status and periodontitis. Human studies in this topic range from epidemiological to treatment studies. This chapter will discuss the poorly researched topic of redox proteins in periodontal diseases and will review the association between measures of oxidative stress and presence of periodontitis. Particular emphasis will be placed on the potential role of periodontal disease pathogenic factors to determine both local and systemic oxidative stress fingerprints, measured as damage to lipids, proteins, or DNA.

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Authors and Affiliations

  1. Periodontology Unit and Department of Clinical Research, University College London (UCL) Eastman Dental Institute and Hospital, 256 Gray’s Inn Road, London, WC1X 8LD, UK

    Luigi Nibali & Nikos Donos

  2. Division of Microbial Diseases, UCL Eastman Dental Institute, 256 Gray’s Inn Road, London, WC1X 8LD, UK

    Brian Henderson

  3. Department of Drug Sciences, Section of Biochemistry, University of Catania, Viale Andrea Doria 6, 95125, Catania, Italy

    Giovanni Li Volti

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  1. Luigi Nibali
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  2. Brian Henderson
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  3. Giovanni Li Volti
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  4. Nikos Donos
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Corresponding authors

Correspondence to Luigi Nibali , Brian Henderson , Giovanni Li Volti or Nikos Donos .

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Editors and Affiliations

  1. Department of Preventive Dentistry, Okayama University Graduate School of Medicine and Pharmaceutical Sciences, Okayama, Japan

    Daisuke Ekuni

  2. Dept of Science and Clinical Specialty Odontostomatology & Biochemistry, Polytechnical University of Marche Faculty of Medicine, Ancona, Italy

    Maurizio Battino

  3. Department of Preventive Dentistry, Okayama Univ Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama, Japan

    Takaaki Tomofuji

  4. Dept of Oral Biological & Medical Scienc Laboratory of Periodontal Biology, University of British Columbia Faculty of Dentistry, Vancouver, British Columbia, Canada

    Edward E. Putnins

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Nibali, L., Henderson, B., Volti, G.L., Donos, N. (2014). Periodontitis and Oxidative Stress: Human Studies. In: Ekuni, D., Battino, M., Tomofuji, T., Putnins, E. (eds) Studies on Periodontal Disease. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-9557-4_9

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