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Expression of Reactive Oxygen Species in Junctional and Pocket Epithelium

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Abstract

The generation of reactive oxygen species (ROS) is part of an antimicrobial response to pathogenic challenge and potentially has a deleterious effect on local periodontal tissues. Junctional epithelial cells in periodontal tissue form the initial defensive line against bacterial challenge. In response to this challenge, junctional epithelial cell proliferation and migration occurs and is a key biological response that is associated with the initiation of periodontal attachment loss. The regulation of this process and its contribution to the initiation and progression of disease are not fully understood, but the local expression of antimicrobial peptides, cytokines, and growth factors is involved. However, the expression of ROS-associated molecules by epithelial cells appears to play a significant role in disease onset as well. In this chapter, we summarize the structural organization of junctional and pocket epithelium, the expression of ROS molecules in this cellular compartment, and their possible roles in mediating periodontal disease onset.

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Acknowledgment

We are grateful to Dr. Noriko Takeuchi (Okayama University, Okayama, Japan) for help creating the figures and to Ms. Ingrid Ellis for her editorial comments.

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Authors and Affiliations

  1. Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan

    Daisuke Ekuni

  2. Department of Oral Biological & Medical Sciences, Faculty of Dentistry, University of British Columbia, 2199 Wesbrook Mall, Vancouver, BC, Canada, V6T 1Z3

    James D. Firth & Edward E. Putnins

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  1. Daisuke Ekuni
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  2. James D. Firth
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  3. Edward E. Putnins
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Correspondence to Edward E. Putnins .

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Editors and Affiliations

  1. Department of Preventive Dentistry, Okayama University Graduate School of Medicine and Pharmaceutical Sciences, Okayama, Japan

    Daisuke Ekuni

  2. Dept of Science and Clinical Specialty Odontostomatology & Biochemistry, Polytechnical University of Marche Faculty of Medicine, Ancona, Italy

    Maurizio Battino

  3. Department of Preventive Dentistry, Okayama Univ Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama, Japan

    Takaaki Tomofuji

  4. Dept of Oral Biological & Medical Scienc Laboratory of Periodontal Biology, University of British Columbia Faculty of Dentistry, Vancouver, British Columbia, Canada

    Edward E. Putnins

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Ekuni, D., Firth, J.D., Putnins, E.E. (2014). Expression of Reactive Oxygen Species in Junctional and Pocket Epithelium. In: Ekuni, D., Battino, M., Tomofuji, T., Putnins, E. (eds) Studies on Periodontal Disease. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-9557-4_4

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