Association Between Oxidative Stress and Periodontal Diseases in Animal Model Studies

  • Manabu Morita
  • Daisuke Ekuni
  • Takaaki Tomofuji
Part of the Oxidative Stress in Applied Basic Research and Clinical Practice book series (OXISTRESS)


Animal models have contributed new knowledge to biological sciences, including periodontology. Rodents, rabbits, pigs, dogs, and nonhuman primates have been used to model human periodontitis, each with advantages and disadvantages. Periodontal disease is commonly induced by placing a bacterial plaque-retentive ligature, by inoculation or injection of human oral bacteria (e.g., Porphyromonas gingivalis), or by applying virulence factors, such as lipopolysaccharide. A number of animal models of periodontitis support the notion that reactive oxygen species play a critical role in periodontitis. In this chapter, we summarize the characteristics of each animal model, their advantages, and the association between oxidative stress and periodontitis in animal model studies.


Periodontal Tissue Gingival Crevicular Fluid Enamel Matrix Derivative Junctional Epithelium Alveolar Bone Loss 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by Grants-in-Aid for Scientific Research (25293427) from the Ministry of Education, Culture, Sports, Science and Technology, Tokyo, Japan.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Manabu Morita
    • 1
  • Daisuke Ekuni
    • 1
  • Takaaki Tomofuji
    • 1
  1. 1.Departments of Preventive DentistryOkayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesKita-kuJapan

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