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Salivary Biomarkers of Oxidative Stress Associated with Periodontal Diseases

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Studies on Periodontal Disease

Abstract

During the past decades salivary research has received a lot of attention due to its possible use as a diagnostic tool for a wide range of oral and systemic diseases. Oxidative stress is defined as an imbalance between antioxidant systems of the body and the production of reactive oxygen species (ROS). Oxidative stress is associated with many systemic or tissue specific conditions such as: cardiac affections, lung related diseases, diabetes, or cancer. Studies show that initiation and development of periodontal disease are also connected with a progressive accumulation of ROS in oral fluids and tissues. Saliva plays an important role in counteracting the effects of oxidative stress through the presence of several antioxidant systems. At the same time, saliva can accurately reflect the oxidative stress status in a pathological situation. The present work describes important salivary functions in the oral environment with a special focus on its diagnostic potential and on the antioxidant defense mechanisms that are connected with the pathogenesis of periodontitis.

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Authors and Affiliations

  1. Faculty of Dental Medicine, Department of Biochemistry, Carol Davila University of Medicine and Pharmacy, No. 8, Blvd. Eroii Sanitari, 050474, Bucharest, Romania

    Maria Greabu & Bogdan Calenic

Authors
  1. Maria Greabu
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  2. Bogdan Calenic
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Correspondence to Maria Greabu or Bogdan Calenic .

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Editors and Affiliations

  1. Department of Preventive Dentistry, Okayama University Graduate School of Medicine and Pharmaceutical Sciences, Okayama, Japan

    Daisuke Ekuni

  2. Dept of Science and Clinical Specialty Odontostomatology & Biochemistry, Polytechnical University of Marche Faculty of Medicine, Ancona, Italy

    Maurizio Battino

  3. Department of Preventive Dentistry, Okayama Univ Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama, Japan

    Takaaki Tomofuji

  4. Dept of Oral Biological & Medical Scienc Laboratory of Periodontal Biology, University of British Columbia Faculty of Dentistry, Vancouver, British Columbia, Canada

    Edward E. Putnins

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Greabu, M., Calenic, B. (2014). Salivary Biomarkers of Oxidative Stress Associated with Periodontal Diseases. In: Ekuni, D., Battino, M., Tomofuji, T., Putnins, E. (eds) Studies on Periodontal Disease. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-9557-4_20

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