Skip to main content
SpringerLink
Log in
Book cover

Studies on Periodontal Disease pp 157–164Cite as

Role of HMGB1 in Periodontal Disease

  • Chapter
  • First Online:

  • 1781 Accesses

Abstract

High-mobility group box-1 (HMGB1) protein is highly expressed in the nucleus, where it regulates chromatin structure and transcription. HMGB1 is also released to the extracellular fluid upon tissue injury or inflammation, and triggers tissue repair and defense programs. The presence of high levels of HMGB1 has been reported in the gingival crevicular fluid (GCF) from periodontal patients and some studies have suggested a role of HMGB1 in inflammatory periodontal tissues. In our previous study, immunohistochemical staining of gingiva showed that HMGB1 is dislocated from the nucleus to the cytoplasm of inflamed epithelial cells in pocket epithelium, whereas it is mainly present in the nucleus in the gingival epithelium. Proliferation of bacteria within the periodontal pocket is closely involved in the exacerbation of periodontal disease. Therefore, the periodontal pocket represents a unique pathological setting for a source of HMGB1 by bacterial insult.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Abbreviations

BA:

Butyric acid

Ca9-22:

Gingival epithelial cells

CHX:

Cycloheximide

CP:

Chronic periodontitis

Cys:

Cysteine

GCF:

Gingival crevicular fluid

HDAC:

Histone deacetylase

HMGB1:

High-mobility group box-1

IL:

Interleukin

LPS:

Lipopolysaccharide

PDL:

Periodontal ligament

RAGE:

Receptor for advanced glycation end products

ROS:

Reactive oxygen species

TNF-α:

Tumor necrosis factor

References

  1. Bianchi ME, Beltrame M (1998) Flexing DNA: HMG-box proteins and their partners. Am J Hum Genet 63:1573–1577

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  2. Bonaldi T, Langst G, Strohner R, Becker PB, Bianchi ME (2002) The DNA chaperone HMGB1 facilitates ACF/CHRAC-dependent nucleosome sliding. EMBO J 21:6865–6873

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  3. Bianchi ME, Manfredi AA (2007) High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity. Immunol Rev 220:35–46

    Article  CAS  PubMed  Google Scholar 

  4. Lotze MT, Tracey KJ (2005) High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nat Rev Immunol 5:331–342

    Article  CAS  PubMed  Google Scholar 

  5. Orlova VV, Choi EY, Xie C et al (2007) A novel pathway of HMGB1-mediated inflammatory cell recruitment that requires Mac-1-integrin. EMBO J 26:1129–1139

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  6. Scaffidi P, Misteli T, Bianchi ME (2002) Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 418:191–195

    Article  CAS  PubMed  Google Scholar 

  7. Wang H, Bloom O, Zhang M et al (1999) HMG-1 as a late mediator of endotoxin lethality in mice. Science 285:248–251

    Article  CAS  PubMed  Google Scholar 

  8. Pullerits R, Jonsson IM, Verdrengh M et al (2003) High mobility group box chromosomal protein 1, a DNA binding cytokine, induces arthritis. Arthritis Rheum 48:1693–1700

    Article  CAS  PubMed  Google Scholar 

  9. Abraham E, Arcaroli J, Carmody A, Wang H, Tracey KJ (2000) HMG-1 as a mediator of acute lung inflammation. J Immunol 165:2950–2954

    Article  CAS  PubMed  Google Scholar 

  10. Bonaldi T, Talamo F, Scaffidi P et al (2003) Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion. EMBO J 22:5551–5560

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  11. Gardella S, Andrei C, Ferrera D et al (2002) The nuclear protein HMGB1 is secreted by monocytes via a non-classical, vesicle-mediated secretory pathway. EMBO Rep 3:995–1001

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  12. Ditsworth D, Zong WX, Thompson CB (2007) Activation of poly(ADP)-ribose polymerase (PARP-1) induces release of the pro-inflammatory mediator HMGB1 from the nucleus. J Biol Chem 282:17845–17854

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  13. Bell CW, Jiang W, Reich CF 3rd, Pisetsky DS (2006) The extracellular release of HMGB1 during apoptotic cell death. Am J Physiol Cell Physiol 291:C1318–C1325

    Article  CAS  PubMed  Google Scholar 

  14. Liu A, Fang H, Dirsch O, Jin H, Dahmen U (2012) Oxidation of HMGB1 causes attenuation of its pro-inflammatory activity and occurs during liver ischemia and reperfusion. PLoS One. doi:10.1371/journal.pone.0035379

    Google Scholar 

  15. Hoppe G, Talcott KE, Bhattacharya SK, Crabb JW, Sears JE (2006) Molecular basis for the redox control of nuclear transport of the structural chromatin protein Hmgb1. Exp Cell Res 312:3526–3538

    Article  CAS  PubMed  Google Scholar 

  16. Kazama H, Ricci JE, Herndon JM et al (2008) Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein. Immunity 29:21–32

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  17. Tang D, Kang R, Zeh HJ III (2011) High-mobility group box 1, oxidative stress, and disease. Antioxid Redox Signal 14:1315–1335

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  18. Venereau E, Casalgrandi M, Schiraldi M et al (2012) Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release. J Exp Med 209:1519–1528

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  19. Tang D, Kang R, Cheh CW et al (2010) HMGB1 release and redox regulates autophagy and apoptosis in cancer cells. Oncogene 29:5299–5310

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  20. Moore WE, Moore LV (1994) The bacteria of periodontal diseases. Periodontol 2000 5:66–77

    Article  CAS  PubMed  Google Scholar 

  21. Page RC (1991) The role of inflammatory mediators in the pathogenesis of periodontal disease. J Periodontal Res 26:230–242

    Article  CAS  PubMed  Google Scholar 

  22. Morimoto Y, Kawahara KI, Tancharoen S et al (2008) Tumor necrosis factor-alpha stimulates gingival epithelial cells to release high mobility-group box 1. J Periodontal Res 43:76–83

    Article  CAS  PubMed  Google Scholar 

  23. Luo L, Xie P, Gong P et al (2011) Expression of HMGB1 and HMGN2 in gingival tissues, GCF and PICF of periodontitis patients and peri-implantitis. Arch Oral Biol 56:1106–1111

    Article  CAS  PubMed  Google Scholar 

  24. Feghali K, Iwasaki K, Tanaka K et al (2009) Human gingival fibroblasts release high-mobility group box-1 protein through active and passive pathways. Oral Microbiol Immunol 24:292–298

    Article  CAS  PubMed  Google Scholar 

  25. Ito Y, Bhawal UK, Sasahira T et al (2012) Involvement of HMGB1 and RAGE in IL-1β-induced gingival inflammation. Arch Oral Biol 57:73–80

    Article  CAS  PubMed  Google Scholar 

  26. Wolf M, Lossdörfer S, Abuduwali N, Jäger A (2012) Potential role of high mobility group box protein 1 and intermittent PTH (1–34) in periodontal tissue repair following orthodontic tooth movement in rats. Clin Oral Investig. doi:10.1007/s00784-012-0777-2

    Google Scholar 

  27. Hasegawa N (2008) Effect of high mobility group box 1 (HMGB1) in cultured human periodontal ligament cells. Kokubyo Gakkai Zasshi 75:155–161

    Article  PubMed  Google Scholar 

  28. Kim YS, Lee YM, Park JS, Lee SK, Kim EC (2010) SIRT1 modulates high-mobility group box 1-induced osteoclastogenic cytokines in human periodontal ligament cells. J Cell Biochem 111:1310–1320

    Article  CAS  PubMed  Google Scholar 

  29. Ebe N, Hara-Yokoyama M, Iwasaki K et al (2011) Pocket epithelium in the pathological setting for HMGB1 release. J Dent Res 90:235–240

    Article  CAS  PubMed  Google Scholar 

  30. Kurita-Ochiai T, Fukushima K, Ochiai K (1995) Volatile fatty acids, metabolic by-products of periodontopathic bacteria, inhibit lymphocyte proliferation and cytokine production. J Dent Res 74:1367–1373

    Article  CAS  PubMed  Google Scholar 

  31. Margolis HC, Duckworth JH, Moreno EC (1988) Composition and buffer capacity of pooled starved plaque fluid from caries-free and caries-susceptible individuals. J Dent Res 67:1476–1482

    Article  CAS  PubMed  Google Scholar 

  32. Qiqiang L, Huanxin M, Xuejun G (2012) Longitudinal study of volatile fatty acids in the gingival crevicular fluid of patients with periodontitis before and after nonsurgical therapy. J Periodontal Res 47:740–749

    Article  CAS  PubMed  Google Scholar 

  33. Chang MC, Tsai YL, Chen YW et al (2013) Butyrate induces reactive oxygen species production and affects cell cycle progression in human gingival fibroblasts. J Periodontal Res 48:66–73

    Article  CAS  PubMed  Google Scholar 

  34. Kurita-Ochiai T, Amano S, Fukushima K, Ochiai K (2003) Cellular events involved in butyric acid-induced T cell apoptosis. J Immunol 171:3576–3584

    Article  CAS  PubMed  Google Scholar 

  35. Takigawa S, Sugano N, Nishihara R et al (2008) The effect of butyric acid on adhesion molecule expression by human gingival epithelial cells. J Periodontal Res 43:386–390

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Inorganic Materials, Institute of Biomaterial & Bioengineering, Tokyo Medical and Dental University (TMDU), 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-0062, Japan

    Noriko Ebe

  2. Section of Biochemistry, Department of Hard Tissue Engineering, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan

    Miki Hara-Yokoyama

  3. Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, 113-8549, Japan

    Yuichi Izumi

Authors
  1. Noriko Ebe
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Miki Hara-Yokoyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yuichi Izumi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yuichi Izumi .

Editor information

Editors and Affiliations

  1. Department of Preventive Dentistry, Okayama University Graduate School of Medicine and Pharmaceutical Sciences, Okayama, Japan

    Daisuke Ekuni

  2. Dept of Science and Clinical Specialty Odontostomatology & Biochemistry, Polytechnical University of Marche Faculty of Medicine, Ancona, Italy

    Maurizio Battino

  3. Department of Preventive Dentistry, Okayama Univ Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama, Japan

    Takaaki Tomofuji

  4. Dept of Oral Biological & Medical Scienc Laboratory of Periodontal Biology, University of British Columbia Faculty of Dentistry, Vancouver, British Columbia, Canada

    Edward E. Putnins

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer Science+Business Media New York

About this chapter

Cite this chapter

Ebe, N., Hara-Yokoyama, M., Izumi, Y. (2014). Role of HMGB1 in Periodontal Disease. In: Ekuni, D., Battino, M., Tomofuji, T., Putnins, E. (eds) Studies on Periodontal Disease. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-9557-4_11

Download citation

Publish with us

Policies and ethics

Search

Navigation