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Intermittent Hypoxia: Mechanistic Pathways Influencing Cancer

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Impact of Sleep and Sleep Disturbances on Obesity and Cancer

Part of the book series: Energy Balance and Cancer ((EBAC,volume 8))

Abstract

Sleep-disordered breathing with recurrent apnea is a major clinical problem affecting 4–5 % of middle-aged men, 2 % of women after menopause [1, 2], and nearly 50 % of premature infants [3]. Recurrent apneas are characterized by transient, repetitive cessations of breathing (10–60 s), which arise either as a consequence of obstruction of the upper airway leading to cessation of airflow (obstructive sleep apnea or OSA) or due to defective respiratory rhythm generation in the brain stem (central apnea). Recurrent apnea produces periodic decreases in arterial blood oxygen or chronic intermittent hypoxia (IH). In severely affected patients, arterial blood O2 saturation can drop as much as 50 %. Comorbidities associated with recurrent apnea include hypertension, elevated sympathetic activity, myocardial infarction, stroke, ventilatory abnormalities, and sudden death in elderly individuals [2].

Association of cancer incidence with sleep disturbances has been documented. For instance, longer sleep duration was shown to be associated with higher incidence colorectal cancer [4–8]. In the recent past, there have been few studies linking OSA and the ensuing IH with cancer [5, 9–11]. The purpose of this chapter is to summarize studies describing the signaling pathways triggered by chronic IH, which may potentially contribute to cancer progression in recurrent apnea patients.

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Acknowledgments

The authors’ research is supported by the National Institutes of Health Grants HL76537, HL90554, and HL86493.

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Authors and Affiliations

  1. Biological Sciences Division, Institute for Integrative Physiology, 5841 S. Maryland Avenue, MC 5068, Room N-711, Chicago, IL, 60637, USA

    Jayasri Nanduri Ph.D. & Nanduri R. Prabhakar Ph.D., D.Sc.

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  1. Jayasri Nanduri Ph.D.
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Correspondence to Nanduri R. Prabhakar Ph.D., D.Sc. .

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Editors and Affiliations

  1. Department of Medicine, Harvard Medical School Brigham and Women's Hospital, Boston, Massachusetts, USA

    Susan Redline

  2. Center for Science, Health & Society, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

    Nathan A. Berger

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Nanduri, J., Prabhakar, N.R. (2014). Intermittent Hypoxia: Mechanistic Pathways Influencing Cancer. In: Redline, S., Berger, N. (eds) Impact of Sleep and Sleep Disturbances on Obesity and Cancer. Energy Balance and Cancer, vol 8. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9527-7_5

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