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Epigenetics of Psychopathology

  • Alicia K. Smith
  • Sasha E. Parets
  • Andrew W. Kim
Chapter
Part of the Advances in Behavior Genetics book series (AIBG, volume 2)

Abstract

Researchers studying mechanisms of learning, behavior, and psychopathology have embraced the field of epigenetics because of its potential to provide insight into mechanisms of pathophysiology, clinical biomarkers, and treatment. This chapter will provide an overview of fundamental concepts in epigenetics including histone modifications, DNA methylation, and microRNA. Because of the association between prenatal or early life stress and varying psychopathologies, it will introduce the concept of epigenetic programming during developmentally sensitive periods with particular emphasis on the role of the glucocorticoid receptor in neuroendocrine stress response. Finally, examples from recent epigenetic studies in mood, anxiety, psychotic, and substance abuse disorders will be used to highlight progress in the field as well as specific challenges in study design and interpretation.

Keywords

Major Depressive Disorder Umbilical Cord Blood Early Life Stress PAC1 Receptor Epigenetic Programming 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Alicia K. Smith
    • 1
    • 2
  • Sasha E. Parets
    • 2
  • Andrew W. Kim
    • 1
  1. 1.Department of Psychiatry and Behavioral SciencesEmory University School of MedicineAtlantaUSA
  2. 2.Genetics and Molecular Biology ProgramEmory UniversityAtlantaUSA

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