Prolonged Duration Local Anesthesia

Part of the Advances in Delivery Science and Technology book series (ADST)


Acute and chronic pain are often treated with local anesthetic agents, whether by injection or topical application. “Conventional” agents (amino-ester and amino-amide local anesthetics) are limited by systemic and local toxicity as well as their short durations of action. For more than 30 years, prolonged duration local anesthesia (PDLA) has been the focus of intense scientific investigation with the goal of enhanced anesthetic duration following a single application. To this end, a broad array of methods has been employed, including the use of nonconventional agents with local anesthetic properties, addition of adjuvants, and controlled release delivery systems. This chapter reviews selected developments in the very extensive field of PDLA.


Hyaluronic Acid Local Anesthetic Encapsulation Efficiency Drug Loading Tissue Reaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Controlled Release Society 2014

Authors and Affiliations

  1. 1.Department of Medicine, Medicine Critical Care ProgramBoston Children’s Hospital, Harvard Medical SchoolBostonUSA
  2. 2.Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care MedicineBoston Children’s Hospital, Harvard Medical School BostonBostonUSA
  3. 3.Division of Health Sciences and TechnologyHarvard-Massachusetts Institute of TechnologyCambridgeUSA

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