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Prolonged Duration Local Anesthesia

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Part of the book series: Advances in Delivery Science and Technology ((ADST))

Abstract

Acute and chronic pain are often treated with local anesthetic agents, whether by injection or topical application. “Conventional” agents (amino-ester and amino-amide local anesthetics) are limited by systemic and local toxicity as well as their short durations of action. For more than 30 years, prolonged duration local anesthesia (PDLA) has been the focus of intense scientific investigation with the goal of enhanced anesthetic duration following a single application. To this end, a broad array of methods has been employed, including the use of nonconventional agents with local anesthetic properties, addition of adjuvants, and controlled release delivery systems. This chapter reviews selected developments in the very extensive field of PDLA.

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Authors and Affiliations

  1. Department of Medicine, Medicine Critical Care Program, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA

    J. Brian McAlvin

  2. Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Boston Children’s Hospital, Harvard Medical School Boston, Boston, MA, USA

    J. Brian McAlvin & Daniel S. Kohane

  3. Division of Health Sciences and Technology, Harvard-Massachusetts Institute of Technology, Cambridge, MA, USA

    J. Brian McAlvin & Daniel S. Kohane

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  1. J. Brian McAlvin
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  2. Daniel S. Kohane
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Correspondence to Daniel S. Kohane .

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Editors and Affiliations

  1. School of Pharmacy-Faculty of Medicine The Hebrew University of Jerusalem, Jerusalem, Israel

    Abraham J. Domb

  2. Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), Balanagar, Hyderabad, Andhra Pradesh, India

    Wahid Khan

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McAlvin, J.B., Kohane, D.S. (2014). Prolonged Duration Local Anesthesia. In: Domb, A., Khan, W. (eds) Focal Controlled Drug Delivery. Advances in Delivery Science and Technology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-9434-8_28

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