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Topical Nanointerventions for Therapeutic and Cosmeceutical Applications

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Focal Controlled Drug Delivery

Part of the book series: Advances in Delivery Science and Technology ((ADST))

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Abstract

The cutaneous manifestation of skin ailments has created a remarkable impetus in the field of topical drug delivery with a rationale to achieve restricted and directed delivery of drugs at the desired site of action. In this context, to further surpass drawbacks associated with inefficient drug delivery via conventional creams, gels and other topical formulations, topical nanodelivery treatment modules are being extensively explored owing to their multifaceted advantages. Herein, this chapter gives a current market and research insight in the field of topical nanointerventions from both therapeutic and cosmeceutical perspective. Additionally, the prime factor being selection of appropriate nanodelivery system, a probable scheme of selection based on literature, is also proposed.

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Abbreviations

AK:

Actinic keratoses

ALA:

5-aminolevulinic acid

BPO:

Benzoyl peroxide

HPV:

Human papilloma virus

HSV:

Herpes simplex virus

MNE:

Magnetic nanoemulsion

MSRA:

Methicillin- resistant staphylococcus aureus

NE:

Nanoemulsion

NLCs:

Nanostructured lipid carriers

NMSC:

Non-melanoma skin cancer

NRC:

Nitrosyl ruthenium complexes

PLGA:

Poly-lactide-co-glycolic acid

PUVA:

Psoralen and UV-A phototherapy

siRNA:

Small interfering RNA

SLNs:

Solid lipid nanoparticles

SNs:

Silver nanoparticles

SOD-2:

Superoxide dismutase 2

TEM:

Transmission electron microscopy

UV:

Ultraviolet

VREF:

Vancomycin- resistant Enterococcus faecalis

α-IFN:

Alpha interferon

γ-IFN:

Gamma interferon

·OH:

Hydroxyl radical

AgNO3 :

Silver nitrate

C60 :

carbon nanostructures fullerenes

IC50 :

Half maximal inhibitory concentration

NO:

Nitric oxide

ZnO:

Zinc oxide

γ-Fe2O3 :

Maghemite

References

  1. Tortora GJ, Derrickson B (2006) The integumentary system. In: Roesh B (ed) Principles of anatomy and physiology, 11th edn. Wiley, NewYork, NY

    Google Scholar 

  2. Venus M, Waterman J, McNab I (2011) Basic physiology of the skin. Surgery 29(10):471–474

    Google Scholar 

  3. Poet TS, McDougal JN (2002) Skin absorption and human risk assessment. Chem Biol Interact 140(1):19–34

    Article  CAS  PubMed  Google Scholar 

  4. Prabhu P, Patravale V, Joshi M (2012) Nanocarriers for effective topical delivery of anti-infectives. Curr Nanosci 8(4):491–503

    Article  CAS  Google Scholar 

  5. Unnithan AR, Barakat NA, Pichiah PB, Gnanasekaran G, Nirmala R, Cha YS, Jung CH, El-Newehy M, Kim HY (2012) Wound-dressing materials with antibacterial activity from electrospun polyurethane-dextran nanofiber mats containing ciprofloxacin HCl. Carbohydr Polym 90(4):1786–1793

    Article  CAS  PubMed  Google Scholar 

  6. Kao J, Hall J, Helman G (1988) In vitro percutaneous absorption in mouse skin: influence of skin appendages. Toxicol Appl Pharmacol 94:93–103

    Article  CAS  PubMed  Google Scholar 

  7. Nabeshi H, Yoshikawa T, Matsuyama K, Nakazato Y, Matsuo K, Arimori A, Isobe M, Tochigi S, Kondoh S, Hirai T, Akase T, Yamashita T, Yamashita K, Yoshida T, Nagano K, Abe Y, Yoshioka Y, Kamada H, Imazawa T, Itoh N, Nakagawa S, Mayumi T, Tsunoda S, Tsutsumi Y (2011) Systemic distribution, nuclear entry and cytotoxicity of amorphous nanosilica following topical application. Biomaterials 32(11):2713–2724

    Article  CAS  PubMed  Google Scholar 

  8. Gupta M, Goyal AK, Paliwal SR, Paliwal R, Mishra N, Vaidya B, Dube D, Jain SK, Vyas SP (2010) Development and characterization of effective topical liposomal system for localized treatment of cutaneous candidiasis. J Liposome Res 20(4):341–350

    Article  CAS  PubMed  Google Scholar 

  9. Du Plessis J, Egbaria K, Ramachandran C, Weiner N (1992) Topical delivery of liposomally encapsulated γ-interferon. Antiviral Res 18(3–4):259–265

    Article  PubMed  Google Scholar 

  10. Yang D, Pornpattananangkul D, Nakatsuji T, Chan M, Carson D, Huang CM, Zhang L (2009) The antimicrobial activity of liposomal lauric acids against propionibacterium acnes. Biomaterials 30(30):6035–6040

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  11. Fang JY, Hwang TL, Huanga YL, Fang CL (2006) Enhancement of the transdermal delivery of catechins by liposomes incorporating anionic surfactants and ethanol. Int J Pharm 310:131–138

    Article  CAS  PubMed  Google Scholar 

  12. Foco A, Gasperlin M, Kristl J (2005) Investigation of liposomes as carriers of sodium ascorbyl phosphate for cutaneous photoprotection. Int J Pharm 291:21–29

    Article  CAS  PubMed  Google Scholar 

  13. Knudsen N, Rønholt S, Salte RD, Jorgensen L, Thormann T, Basse LH, Hansen J, Frokjaer S, Foged C (2012) Calcipotriol delivery into the skin with PEGylated liposomes. Eur J Pharm Biopharm 81(3):532–539

    Article  CAS  PubMed  Google Scholar 

  14. Manosroi A, Kongkaneramit L, Manosroi J (2004) Stability and transdermal absorption of topical amphotericin B liposome formulations. Int J Pharm 270(1–2):279–286

    Article  CAS  PubMed  Google Scholar 

  15. Montanari J, Maidana C, Esteva MI, Salomon C, Morilla MJ, Romero EL (2010) Sunlight triggered photodynamic ultradeformable liposomes against Leishmania braziliensis are also leishmanicidal in the dark. J Control Release 147(3):368–376

    Article  CAS  PubMed  Google Scholar 

  16. Verma P, Pathak K (2012) Nanosized ethanolic vesicles loaded with econazole nitrate for the treatment of deep fungal infections through topical gel formulation. Nanomedicine 8(4):489–496

    Article  CAS  PubMed  Google Scholar 

  17. Maheshwari RGS, Tekade RK, Sharma PA, Darwhekar G, Tyagi A, Patel RP, Jain DK (2012) Ethosomes and ultradeformable liposomes for transdermal delivery of clotrimazole: a comparative assessment. Saudi Pharm J 20(2):161–170

    Article  PubMed Central  PubMed  Google Scholar 

  18. Fang YP, Huang YB, Wu PC, Tsai YH (2009) Topical delivery of 5-aminolevulinic acid-encapsulated ethosomes in a hyperproliferative skin animal model using the CLSM technique to evaluate the penetration behaviour. Eur J Pharm Biopharm 73(3):391–398

    Article  CAS  PubMed  Google Scholar 

  19. Paolino D, Celia C, Trapasso E, Cilurzo F, Fresta M (2012) Paclitaxel-loaded ethosomes®: potential treatment of squamous cell carcinoma, a malignant transformation of actinic keratoses. Eur J Pharm Biopharm 81(1):102–112

    Article  CAS  PubMed  Google Scholar 

  20. Bavarsad N, Fazly Bazzaz BS, Khamesipour A, Jaafari MR (2012) Colloidal, in vitro and in vivo anti-leishmanial properties of transfersomes containing paromomycin sulfate in susceptible BALB/c mice. Acta Trop 124(1):33–41

    Article  CAS  PubMed  Google Scholar 

  21. Kaur CD, Saraf S (2011) Topical vesicular formulations of Curcuma longa extract on recuperating the ultraviolet radiation-damaged skin. J Cosmet Dermatol 10(4):260–265

    Article  PubMed  Google Scholar 

  22. Kilfoyle BE, Sheihet L, Zhang Z, Laohoo M, Kohn J, Michniak-Kohn BB (2012) Development of paclitaxel-TyroSpheres for topical skin treatment. J Control Release 163(1):18–24. doi:10.1016/j.jconrel.2012.06.021

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  23. Manconi M, Valenti D, Sinico C, Lai F, Loy G, Fadda AM (2003) Niosomes as carriers for tretinoin II. Influence of vesicular incorporation on tretinoin photostability. Int J Pharm 260:261–272

    Article  CAS  PubMed  Google Scholar 

  24. Souto EB, Wissing SA, Barbosa CM, Müller RH (2004) Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery. Int J Pharm 278(1):71–77

    Article  CAS  PubMed  Google Scholar 

  25. Fang JY, Fang CL, Liu CH, Su YH (2008) Lipid nanoparticles as vehicles for topical psoralen delivery: solid lipid nanoparticles (SLN) versus nanostructured lipid carriers (NLC). Eur J Pharm Biopharm 70(2):633–640

    Article  CAS  PubMed  Google Scholar 

  26. Marquele-Oliveira F, Santana DC, Taveira SF, Vermeulen DM, de Oliveira AR, da Silva RS, Lopez RF (2010) Development of nitrosyl ruthenium complex-loaded lipid carriers for topical administration: improvement in skin stability and in nitric oxide release by visible light irradiation. J Pharm Biomed Anal 53(4):843–851

    Article  CAS  PubMed  Google Scholar 

  27. Gupta M, Vyas SP (2012) Development, characterization and in vivo assessment of effective lipidic nanoparticles for dermal delivery of fluconazole against cutaneous candidiasis. Chem Phys Lipids 165(4):454–461

    Article  CAS  PubMed  Google Scholar 

  28. Castro GA, Coelho AL, Oliveira CA, Mahecha GA, Oréfice RL, Ferreira LA (2009) Formation of ion pairing as an alternative to improve encapsulation and stability and to reduce skin irritation of retinoic acid loaded in solid lipid nanoparticles. Int J Pharm 381(1):77–83

    Article  CAS  PubMed  Google Scholar 

  29. Czermak P, Steinle T, Ebrahimi M, Schmidts T, Runkel F (2010) Membrane-assisted production of S1P loaded SLNs for the treatment of acne vulgaris. Desalination 250(3):1132–1135

    Article  CAS  Google Scholar 

  30. Teskac K, Kristl J (2010) The evidence for solid lipid nanoparticles mediated cell uptake of resveratrol. Int J Pharm 390:61–69

    Article  CAS  PubMed  Google Scholar 

  31. Mei Z, Wu Q, Hu S, Li X, Yang X (2005) Triptolide loaded solid lipid nanoparticles hydrogel for topical application. Drug Dev Ind Pharm 31:161–168

    Article  CAS  PubMed  Google Scholar 

  32. Joshi M, Patravale V (2008) Nanostructured lipid carrier (NLC) based gel of celecoxib. Int J Pharm 346(1–2):124–132

    Article  CAS  PubMed  Google Scholar 

  33. Agrawal Y, Petkar KC, Sawant KK (2010) Development, evaluation and clinical studies of Acitretin loaded nanostructured lipid carriers for topical treatment of psoriasis. Int J Pharm 401(1–2):93–102

    Article  CAS  PubMed  Google Scholar 

  34. Foldvari M (2012) HPV infections: can they be eradicated using nanotechnology? Nanomedicine 8(2):131–135

    Article  CAS  PubMed  Google Scholar 

  35. Schwarz JC, Klang V, Karall S, Mahrhauser D, Resch GP, Valenta C (2012) Optimisation of multiple W/O/W nanoemulsions for dermal delivery of aciclovir. Int J Pharm 435(1):69–75

    Article  CAS  PubMed  Google Scholar 

  36. Fang JY, Leu YL, Chang CC, Lin CH, Tsai YH (2004) Lipid nano/submicron emulsions as vehicles for topical flurbiprofen delivery. Drug Deliv 11(2):97–105

    Article  CAS  PubMed  Google Scholar 

  37. Yu A, Guo C, Zhou Y, Cao F, Zhu W, Sun M, Zhai G (2010) Skin irritation and the inhibition effect on HSV-1 in vivo of penciclovir-loaded microemulsion. Int Immunopharmacol 10(10):1305–1309

    Article  CAS  PubMed  Google Scholar 

  38. Spiclin P, Homar M, Zupancic-Valant A, Gasperlin M (2003) Sodium ascorbyl phosphate in topical microemulsions. Int J Pharm 256:65–73

    Article  CAS  PubMed  Google Scholar 

  39. Primo FL, Michieleto L, Rodrigues MAM, Macaroff PP, Morais PC, Lacava ZGM, Bentley MVLB, Tedesco AC (2007) Magnetic nanoemulsions as drug delivery system for Foscan®: skin permeation and retention in vitro assays for topical application in photodynamic therapy (PDT) of skin cancer. J Magn Magn Mater 311(1):354–357

    Article  CAS  Google Scholar 

  40. Primo FL, Rodrigues MAM, Simioni AR, Andreza R, Bentley MVLB, Morais PC, Tedesco AC (2008) In vitro studies of cutaneous retention of magnetic nanoemulsion loaded with zinc phthalocyanine for synergic use in skin cancer treatment. J Magn Magn Mater 320(14):e211–e214

    Article  CAS  Google Scholar 

  41. Mou D, Chen H, Du D, Mao C, Wan J, Xu H, Yang X (2008) Hydrogel-thickened nanoemulsion system for topical delivery of lipophilic drugs. Int J Pharm 353(1–2):270–276

    Article  CAS  PubMed  Google Scholar 

  42. Marangoci N, Mares M, Silion M, Fifere A, Varganici C, Nicolescu A, Deleanu C, Coroaba A, Pinteala M, Simionescu BC (2011) Inclusion complex of a new propiconazole derivative with β-cyclodextrin: NMR, ESI–MS and preliminary pharmacological studies. Results Pharma Sci 1(1):27–37

    Article  CAS  Google Scholar 

  43. Shah PP, Desai PR, Patel AR, Singh MS (2012) Skin permeating nanogel for the cutaneous co-delivery of two anti-inflammatory drugs. Biomaterials 33(5):1607–1617

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  44. Nhung DT, Freydiere AM, Constant H, Falson F, Pirot F (2007) Sustained antibacterial effect of a hand rub gel incorporating chlorhexidine-loaded nanocapsules (Nanochlorex). Int J Pharm 334(1–2):166–172

    Article  CAS  PubMed  Google Scholar 

  45. Chiappetta DA, Degrossi J, Teves S, D’Aquino M, Bregni C, Sosnik A (2008) Triclosan-loaded poloxamine micelles for enhanced topical antibacterial activity against biofilm. Eur J Pharm Biopharm 69(2):535–545

    Article  CAS  PubMed  Google Scholar 

  46. Mohammadi G, Nokhodchi A, Barzegar-Jalali M, Lotfipour F, Adibkia K, Ehyaei N, Valizadeh H (2011) Physicochemical and anti-bacterial performance characterization of clarithromycin nanoparticles as colloidal drug delivery system. Colloids Surf B Biointerfaces 88(1):39–44

    Article  CAS  PubMed  Google Scholar 

  47. Hillaireau H, Le Doan T, Besnard M, Chacun H, Janin J, Couvreur P (2006) Encapsulation of antiviral nucleotide analogues azidothymidine-triphosphate and cidofovir in poly(iso-butylcyanoacrylate) nanocapsules. Int J Pharm 324(1):37–42

    Article  CAS  PubMed  Google Scholar 

  48. Abdel-Mottaleb MM, Moulari B, Beduneau A, Pellequer Y, Lamprecht A (2012) Nanoparticles enhance therapeutic outcome in inflamed skin therapy. Eur J Pharm Biopharm 82(1):151–157

    Article  CAS  PubMed  Google Scholar 

  49. Domínguez-Delgado CL, Rodríguez-Cruz IM, Escobar-Chávez JJ, Calderón-Lojero IO, Quintanar-Guerrero D, Ganem A (2011) Preparation and characterization of triclosan nanoparticles intended to be used for the treatment of acne. Eur J Pharm Biopharm 79(1):102–107

    Article  PubMed  Google Scholar 

  50. Choi WI, Lee JH, Kim JY, Kim JC, Kim YH, Tae G (2012) Efficient skin permeation of soluble proteins via flexible and functional nano-carrier. J Control Release 157(2):272–278

    Article  CAS  PubMed  Google Scholar 

  51. Strydom SJ, Rose WE, Otto DP, Liebenberg W, de Villiers MM (2012) Poly(amidoamine) dendrimer-mediated synthesis and stabilization of silver sulfonamide nanoparticles with increased antibacterial activity. Nanomedicine. doi:10.1016/j.nano.2012.03.006

    PubMed  Google Scholar 

  52. Mirzajani F, Ghassempour A, Aliahmadi A, Esmaeili MA (2011) Antibacterial effect of silver nanoparticles on Staphylococcus aureus. Res Microbiol 162(5):542–549

    Article  CAS  PubMed  Google Scholar 

  53. Ravindran A, Chandran P, Khan SS (2012) Biofunctionalized silver nanoparticles: advances and prospects. Colloids Surf B Biointerfaces 105:342–52. doi:10.1016/j.colsurfb.2012.07.036

    Article  PubMed  Google Scholar 

  54. Vijayakumar M, Priya K, Nancy FT, Noorlidah A, Ahmed ABA (2013) Biosynthesis, characterisation and anti-bacterial effect of plant-mediated silver nanoparticles using Artemisia nilagirica. Ind Crop Prod 41:235–240

    Article  CAS  Google Scholar 

  55. Sadeghi B, Garmaroudi FS, Hashemi M, Nezhad HR, Nasrollahi A, Ardalan S, Ardalan S (2012) Comparison of the anti-bacterial activity on the nanosilver shapes: nanoparticles, nanorods and nanoplates. Adv Powder Technol 23(1):22–26

    Article  CAS  Google Scholar 

  56. Rai M, Yadav A, Gade A (2009) Silver nanoparticles as a new generation of antimicrobials. Biotechnol Adv 27(1):76–83

    Article  CAS  PubMed  Google Scholar 

  57. Zhao L, Wang H, Huo K, Cui L, Zhang W, Ni H, Zhang Y, Wu Z, Chu PK (2011) Antibacterial nano-structured titania coating incorporated with silver nanoparticles. Biomaterials 32(24):5706–5716

    Article  CAS  PubMed  Google Scholar 

  58. Hbaieb S, Kalfat R, Chevalier Y (2012) Loading antifungal drugs onto silica particles grafted with cyclodextrins by means of inclusion complex formation at the solid surface. Int J Pharm 439(1–2):234–45. doi:10.1016/j.ijpharm.2012.09.035

    Article  CAS  PubMed  Google Scholar 

  59. Mishra YK, Adelung R, Röhl C, Shukla D, Spors F, Tiwari V (2011) Virostatic potential of micro-nano filopodia-like ZnO structures against herpes simplex virus-1. Antiviral Res 92(2):305–312

    Article  CAS  PubMed  Google Scholar 

  60. Inui S, Aoshima H, Nishiyama A, Itami S (2011) Improvement of acne vulgaris by topical fullerene application: unique impact on skin care. Nanomedicine 7(2):238–241

    Article  CAS  PubMed  Google Scholar 

  61. Ridolfi DM, Marcato PD, Justo GZ, Cordi L, Machado D, Durán N (2012) Chitosan-solid lipid nanoparticles as carriers for topical delivery of tretinoin. Colloids Surf B Biointerfaces 93:36–40

    Article  CAS  PubMed  Google Scholar 

  62. Gopinath D, Ravia D, Rao BR, Apte SS, Renuka D, Rambhaua D (2004) Ascorbyl palmitate vesicles (Aspasomes), formation, characterization and applications. Int J Pharm 271:95–113

    Article  CAS  PubMed  Google Scholar 

  63. Yang F, Kamiya N, Goto M (2012) Transdermal delivery of the anti-rheumatic agent methotrexate using a solid-in-oil nanocarrier. Eur J Pharm Biopharm 82(1):158–163

    Article  CAS  PubMed  Google Scholar 

  64. Desai PP, Date AA, Patravale VB (2012) Overcoming poor oral bioavailability using nanoparticle formulations-opportunities and limitations. Drug Discov Today Technol 9(2):e87–e95

    Article  CAS  Google Scholar 

  65. Higa LH, Schilrreff P, Perez AP, Iriarte MA, Roncaglia DI, Morilla MJ, Romero EL (2012) Ultradeformable archaeosomes as new topical adjuvants. Nanomedicine 8(8):1319–1328

    Article  CAS  PubMed  Google Scholar 

  66. Li N, Peng LH, Chen X, Nakagawa S, Gao JQ (2011) Transcutaneous vaccines: novel advances in technology and delivery for overcoming the barriers. Vaccine 29(37):6179–6190

    Article  CAS  PubMed  Google Scholar 

  67. Bhagavatula M, Powell C (2011) Common superficial skin infections and infestations. Paediatr Child Health 21(3):132–136

    Article  Google Scholar 

  68. Fluhr JW, Barsom O, Gehring W, Gloor M (1999) Antibacterial efficacy of benzoyl peroxide in phospholipid liposomes. A vehicle-controlled, comparative study in patients with papulopustular acne. Dermatology 198:273–277

    Article  CAS  PubMed  Google Scholar 

  69. Godin B, Touitou E, Rubinstein E, Athamna A, Athamna M (2005) A new approach for treatment of deep skin infections by an ethosomal antibiotic preparation: an in vivo study. J Antimicrob Chemother 55(6):989–994

    Article  CAS  PubMed  Google Scholar 

  70. Armijos RX, Weigel MM, Calvopiña M, Mancheno M, Rodriguez R (2004) Comparison of the effectiveness of two topical paromomycin treatments versus meglumine antimoniate for new world cutaneous leishmaniasis. Acta Trop 91(2):153–160

    Article  CAS  PubMed  Google Scholar 

  71. Frézard F, Martins PS, Bahia AP, Le Moyec L, de Melo AL, Pimenta AM, Salerno M, da Silva JB, Demicheli C (2008) Enhanced oral delivery of antimony from meglumine antimoniate/β-cyclodextrin nanoassemblies. Int J Pharm 347(1–2):102–108

    Article  PubMed  Google Scholar 

  72. Yardley V, Croft SL (2000) A comparison of the activities of three amphotericin B lipid formulations against experimental visceral and cutaneous leishmaniasis. Int J Antimicrob Agents 13(4):243–248

    Article  CAS  PubMed  Google Scholar 

  73. Mendonça CO, Burden AD (2003) Current concepts in psoriasis and its treatment. Pharmacol Ther 99(2):133–147

    Article  PubMed  Google Scholar 

  74. Rastogi R, Anand S, Koul V (2009) Flexible polymerosomes-an alternative vehicle for topical delivery. Colloids Surf B Biointerfaces 72(1):161–166

    Article  CAS  PubMed  Google Scholar 

  75. Arora MK, Yadav A, Saini V (2011) Role of hormones in acne vulgaris. Clin Biochem 44(13):1035–1040

    Article  CAS  PubMed  Google Scholar 

  76. Thiboutot D, Gollnick H, Bettoli V, Dréno B, Kang S, Leyden JJ, Shalita AR, Lozada VT, Berson D, Finlay A, Goh CL, Herane MI, Kaminsky A, Kubba R, Layton A, Miyachi Y, Perez M, Martin JP, Ramos-E-Silva M, See JA, Shear N, Wolf J Jr, Global Alliance to Improve Outcomes in Acne (2009) New insights into the management of acne: an update from the global alliance to improve outcomes in Acne group. J Am Acad Dermatol 60:S1–S50

    Article  PubMed  Google Scholar 

  77. Azimi H, Fallah-Tafti M, Khakshur AA, Abdollahi M (2012) A review of phytotherapy of acne vulgaris: perspective of new pharmacological treatments. Fitoterapia. doi:10.1016/j.fitote.2012.03.026

    PubMed  Google Scholar 

  78. Ghersetich I, Troiano M, De Giorgi V, Lotti T (2007) Receptors in skin ageing and antiageing agents. Dermatol Clin 25(4):655–662

    Article  CAS  PubMed  Google Scholar 

  79. Kaur IP, Kapila M, Agrawal R (2007) Role of novel delivery systems in developing topical antioxidants as therapeutics to combat photoageing. Ageing Res Rev 6(4):271–288

    Article  CAS  PubMed  Google Scholar 

  80. Raut S, Singh Bhadoriya SS, Uplanchiwar V, Mishra V, Gahane A, Jain SK (2012) Lecithin organogel: a unique micellar system for the delivery of bioactive agents in the treatment of skin aging. Acta Pharm Sin B 2(1):8–15

    CAS  Google Scholar 

  81. Gruber J, Fong S, Chen CB, Yoong S, Pastorin G, Schaffer S, Cheah I, Halliwell B (2012) Mitochondria-targeted antioxidants and metabolic modulators as pharmacological interventions to slow ageing. Biotechnol Adv. doi:10.1016/j.biotechadv.2012.09.005

    PubMed  Google Scholar 

  82. Yue Y, Zhoua H, Liu G, Li Y, Yan Z, Duan M (2010) The advantages of a novel CoQ10 delivery system in skin photo-protection. Int J Pharm 392 (1-2): 57–63

    Article  CAS  PubMed  Google Scholar 

  83. Moddaresi M, Tamburic S, Williams S, Jones SA, Zhao Y, Brown MB (2009) Effects of lipid nanocarriers on the performance of topical vehicles in vivo. J Cosmet Dermatol 8(2):136–143

    Article  PubMed  Google Scholar 

  84. Andrievsky GV, Bruskov VI, Tykhomyrov AA, Gudkov SV (2009) Peculiarities of the antioxidant and radioprotective effects of hydrated C60 fullerene nanostructures in vitro and in vivo. Free Radic Biol Med 47(6):786–793

    Article  CAS  PubMed  Google Scholar 

  85. Cirillo G, Hampel S, Klingeler R, Puoci F, Iemma F, Curcio M, Parisi OI, Spizzirri UG, Picci N, Leonhardt A, Ritschel M, Büchner B (2011) Antioxidant multi-walled carbon nanotubes by free radical grafting of gallic acid: new materials for biomedical applications. J Pharm Pharmacol 63(2):179–188

    Article  CAS  PubMed  Google Scholar 

  86. Colon J, Hsieh N, Ferguson A, Kupelian P, Seal S, Jenkins DW, Baker CH (2010) Cerium oxide nanoparticles protect gastrointestinal epithelium from radiation-induced damage by reduction of reactive oxygen species and upregulation of superoxide dismutase 2. Nanomedicine 6(5):698–705

    Article  CAS  PubMed  Google Scholar 

  87. Fathi-Azarbayjani A, Qun L, Chan YW, Chan SY (2010) Novel vitamin and gold-loaded nanofiber facial mask for topical delivery. AAPS PharmSciTech 11(3):1164–1170

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  88. Piao H, Kamiya N, Cui F, Goto M (2011) Preparation of a solid-in-oil nanosuspension containing L-ascorbic acid as a novel long-term stable topical formulation. Int J Pharm 420(1):156–160

    Article  CAS  PubMed  Google Scholar 

  89. Hirai T, Yoshikawa T, Nabeshi H, Yoshida T, Akase T, Yoshioka Y, Itoh N, Tsutsumi Y (2012) Dermal absorption of amorphous nanosilica particles after topical exposure for three days. Pharmazie 67(8):742–743

    CAS  PubMed  Google Scholar 

  90. Nohynek GJ, Lademann J, Ribaud C, Roberts MS (2007) Grey goo on the skin? Nanotechnology, cosmetic and sunscreen safety. Crit Rev Toxicol 37(3):251–277

    Article  CAS  PubMed  Google Scholar 

  91. Zvyagin AV, Zhao X, Gierden A, Sanchez W, Ross JA, Roberts MS (2008) Imaging of zinc oxide nanoparticle penetration in human skin in vitro and in vivo. J Biomed Opt 13(6):064031

    Article  PubMed  Google Scholar 

  92. Zinc oxide & nanoparticles in sunscreens. Badgerbalm. http://www.badgerbalm.com/s-33-zinc-oxide-and-nanoparticles.aspx. Accessed 31 Oct 2012

  93. Badea I, Wettig S, Verrall R, Foldvari M (2007) Topical non-invasive gene delivery using gemini nanoparticles in interferon-γ-deficient mice. Eur J Pharm Biopharm 65(3):414–422

    Article  CAS  PubMed  Google Scholar 

  94. Vicentini FT, Depieri LV, Polizello AC, Ciampo JO, Spadaro AC, Fantini MC, Vitória Lopes Badra Bentley M (2012) Liquid crystalline phase nanodispersions enable skin delivery of siRNA. Eur J Pharm Biopharm. doi:10.1016/j.ejpb.2012.08.011

    Google Scholar 

  95. Rodríguez G, Barbosa-Barros L, Rubio L, Cócera M, López-Iglesias C, de la Maza A, López O (2011) Bicellar systems as modifiers of skin lipid structure. Colloids Surf B Biointerfaces 84(2):390–394

    Article  PubMed  Google Scholar 

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  1. Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Nathalal Parekh Marg, Matunga, Mumbai, 400 019, India

    Vandana B. Patravale & Preshita P. Desai

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  1. Vandana B. Patravale
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  2. Preshita P. Desai
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Correspondence to Vandana B. Patravale .

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  1. School of Pharmacy-Faculty of Medicine The Hebrew University of Jerusalem, Jerusalem, Israel

    Abraham J. Domb

  2. Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), Balanagar, Hyderabad, Andhra Pradesh, India

    Wahid Khan

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© 2014 Controlled Release Society

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Patravale, V.B., Desai, P.P. (2014). Topical Nanointerventions for Therapeutic and Cosmeceutical Applications. In: Domb, A., Khan, W. (eds) Focal Controlled Drug Delivery. Advances in Delivery Science and Technology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-9434-8_24

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