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Polymer-Based Drug Delivery Systems for Solid Tumor Treatment

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Focal Controlled Drug Delivery

Part of the book series: Advances in Delivery Science and Technology ((ADST))

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Abstract

Cytotoxic chemo- or radiotherapy of cancer is limited by serious, sometimes life-threatening, side effects that arise from toxicities to healthy tissues because the therapies are not selective for malignant cells. In this chapter we described the use of polymeric drug delivery systems (DDSs) for anticancer drugs that are used to treat solid tumors either locally or systemically. Locally injected formulations have increased the concentration of the drug at the tumor site, while systemically injected nanoparticles can also passively or actively target undetected metastases. We presented a thorough discussion of different types of in situ forming injectable hydrogels, followed by various micro- and nanoparticulate systems. Finally, the role of polymeric DDS in addressing the multidrug resistance, different cell populations in the tumor, and angiogenesis by delivering combined therapeutic agents was also discussed.

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Abbreviations

ASGP:

Asialoglycoprotein

CSC:

Cancer stem cells

DDS:

Drug delivery system

DOX:

Doxorubicin

ECM:

Extracellular matrix

ELP:

Elastin-like polypeptides

EPR (effect):

Enhanced permeability and retention (effect)

GI:

Gastrointestinal

HMDI:

Hexamethylene diisocyanate

HPMA:

N-(2-Hydroxypropyl)methacrylamide

IT:

Intratumoral

LCST:

Low critical solution temperature

MAbs:

Monoclonal antibodies

MPEG:

Methyl poly(ethylene glycol)

Mr:

Relative molecular mass

Mw:

Molecular Weight

NP:

Nanoparticles

PCL:

Poly(ε-caprolactone)

PEA:

Poly(ethylene adipate)

PEO:

Poly(ethylene oxide)

PEG:

Poly(ethylene glycol)

PES:

Poly(ethylene succinate)

PHA:

Poly(hexamethylene adipate)

PK:

Pharmacokinetics

PLGA:

Poly(lactic-co-glycolic acid)

PLLA:

Poly(l-lactic acid)

PNIPAM:

Poly(N-isopropylacrylamide)

RA:

Ricinoleic acid

SA:

Sebacic acid

PSA:

Poly(sebacic acid)

UCST:

Low critical solution temperature

VEGF:

Vascular endothelial growth factor

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Authors and Affiliations

  1. The Department of Biomedical Engineering, University of Michigan, 1101 Beal Avenue, Ann Arbor, MI, 48109, USA

    Ariella Shikanov

  2. Institute of Drug Research, School of Pharmacy-Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, 91120, Israel

    Abraham J. Domb

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  1. Ariella Shikanov
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Correspondence to Ariella Shikanov .

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Editors and Affiliations

  1. School of Pharmacy-Faculty of Medicine The Hebrew University of Jerusalem, Jerusalem, Israel

    Abraham J. Domb

  2. Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), Balanagar, Hyderabad, Andhra Pradesh, India

    Wahid Khan

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Shikanov, A., Domb, A.J. (2014). Polymer-Based Drug Delivery Systems for Solid Tumor Treatment. In: Domb, A., Khan, W. (eds) Focal Controlled Drug Delivery. Advances in Delivery Science and Technology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-9434-8_23

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