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Antibiotics Delivery for Treating Bone Infections

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Book cover Focal Controlled Drug Delivery

Part of the book series: Advances in Delivery Science and Technology ((ADST))

Abstract

Osteomyelitis is an infection of bone and bone marrow. It is attributed to several factors: antibiotic short half-life, poor blood circulation at the infected area, and systemic antibiotic toxicity usage of the required high systemic dose. All evocating osteomyelitis presents an additional challenge, because the infecting bacteria form a biofilm mode of growth, which, on devascularized surfaces, shields them from antibiotics. Widespread research is currently being conducted on local drug delivery systems to treat osteomyelitis. By utilizing newer forms of sustained-release antibiotic delivery systems, it will be possible to deliver such antibiotics at constant rates over a prolonged period of time and eliminate the need for multiple dosing.

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Authors and Affiliations

  1. Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500037, India

    Wahid Khan & Venu Gopala Swami Challa

  2. Department of Chemistry, Deogiri College, Aurangabad, India

    Rajendra P. Pawar

  3. Department of Orthopaedic Surgery, Meir Medical Center, Tel Aviv University, Kfar-Saba, Israel

    Meir Nyska & Yaron S. Brin

  4. Faculty of Medicine, Institute of Drug Research, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, 91120, Israel

    Abraham J. Domb

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  1. Wahid Khan
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  2. Venu Gopala Swami Challa
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  3. Rajendra P. Pawar
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  4. Meir Nyska
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  5. Yaron S. Brin
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  6. Abraham J. Domb
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Correspondence to Abraham J. Domb .

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Editors and Affiliations

  1. School of Pharmacy-Faculty of Medicine The Hebrew University of Jerusalem, Jerusalem, Israel

    Abraham J. Domb

  2. Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), Balanagar, Hyderabad, Andhra Pradesh, India

    Wahid Khan

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Khan, W., Challa, V.G.S., Pawar, R.P., Nyska, M., Brin, Y.S., Domb, A.J. (2014). Antibiotics Delivery for Treating Bone Infections. In: Domb, A., Khan, W. (eds) Focal Controlled Drug Delivery. Advances in Delivery Science and Technology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-9434-8_21

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