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Nanotechnology Applications in Local Arterial Drug Delivery

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Focal Controlled Drug Delivery

Part of the book series: Advances in Delivery Science and Technology ((ADST))

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Abstract

Disorders of the cardiovascular system are identified as the primary cause of fatal conditions, such as atherosclerosis, myocardial infarction, and stroke. It is mainly the damage of the arterial vascular system that leads to the development of many of these fatal diseases. Abnormalities in the arterial system directly affects blood circulation and ultimately results in irreversible peripheral organ or tissue damage. This review describes the challenges and opportunities in systemic and local drug delivery to the arterial tissue. Based on the unique anatomical and physiological constraints, advances in systemic (e.g., targeted nanotechnology-based formulations) and local (e.g., drug-eluting stent implantation) delivery technologies have provided insights into arterial therapeutic approaches, especially in coronary restenosis. Significant opportunities exist in further development of multifunctional nanosystems that can be incorporated with localized delivery strategies, such as double-balloon catheters, to improve drug residence and intracellular availability.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA, 02115, USA

    Dipti Deshpande, Aziza Jamal-Allial & Kinjal Sankhe

  2. Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, 140 The Fenway Building, Room 156, 360 Huntington Avenue, Boston, MA, 02115, USA

    Mansoor Amiji

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  1. Dipti Deshpande
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  2. Aziza Jamal-Allial
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  3. Kinjal Sankhe
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  4. Mansoor Amiji
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Correspondence to Mansoor Amiji .

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  1. School of Pharmacy-Faculty of Medicine The Hebrew University of Jerusalem, Jerusalem, Israel

    Abraham J. Domb

  2. Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), Balanagar, Hyderabad, Andhra Pradesh, India

    Wahid Khan

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Deshpande, D., Jamal-Allial, A., Sankhe, K., Amiji, M. (2014). Nanotechnology Applications in Local Arterial Drug Delivery. In: Domb, A., Khan, W. (eds) Focal Controlled Drug Delivery. Advances in Delivery Science and Technology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-9434-8_17

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