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Focal Controlled Drug Delivery pp 343–357Cite as

Segmental-Dependent Drug Absorption and Delivery: The Intestinal Tract

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Part of the book series: Advances in Delivery Science and Technology ((ADST))

Abstract

The intestinal tract is a long and complex organ, with significantly variable characteristics throughout it. It is broadly divided to several segments: the small intestine, which is subdivided to duodenum, jejunum, and ileum, and the colon. Each segment has its own unique environment. Conditions in each segment are dependent on a multitude of factors. This chapter surveys three such factors: environmental pH values, transporter expression levels, and CYP3A4 expression. Their influence on drug absorption is discussed, and technologies to exploit them for optimization of absorption are reviewed. In conclusion, segment-specific drug absorption and delivery is a highly important research field; a thorough understanding of the determinants of intestinal environment, considering the whole of the human intestine, is crucial for successful targeting of drugs to specific intestinal regions and exploitation of the variable intestinal conditions for better drug delivery and therapeutic effect.

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Author information

Authors and Affiliations

  1. Department of Clinical Pharmacology, School of Pharmacy, Faculty of Health Sciences, Ben-Gurion University of the Negev, 653, Beer-Sheva, 84105, Israel

    Omri Wolk & Arik Dahan Ph.D.

Authors
  1. Omri Wolk
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  2. Arik Dahan Ph.D.
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Corresponding author

Correspondence to Arik Dahan Ph.D. .

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Editors and Affiliations

  1. School of Pharmacy-Faculty of Medicine The Hebrew University of Jerusalem, Jerusalem, Israel

    Abraham J. Domb

  2. Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), Balanagar, Hyderabad, Andhra Pradesh, India

    Wahid Khan

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Wolk, O., Dahan, A. (2014). Segmental-Dependent Drug Absorption and Delivery: The Intestinal Tract. In: Domb, A., Khan, W. (eds) Focal Controlled Drug Delivery. Advances in Delivery Science and Technology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-9434-8_16

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