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Topical Iontophoresis for Targeted Local Drug Delivery to the Eye and Skin

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Book cover Focal Controlled Drug Delivery

Part of the book series: Advances in Delivery Science and Technology ((ADST))

Abstract

Iontophoresis is a noninvasive technique that involves the application of a mild electric current to enhance the penetration of hydrosoluble molecules into and through tissues, enabling a targeted delivery while minimizing systemic distribution of drugs, which makes it very attractive for the targeted treatment of local conditions by topical delivery. This means that iontophoresis is a very useful technique both for the treatment of dermatological conditions, e.g., those requiring very toxic therapeutic agents, such as skin cancers, and for the local delivery of cosmeceuticals. Topical therapies are also preferred in the case of ophthalmic diseases due to possible toxicity following systemic administration and the low bioavailability due to the blood–retina barrier. In this chapter the basic concepts and transport mechanisms behind iontophoresis are presented, and recent studies investigating topical iontophoretic delivery to the skin and the eye are reviewed and discussed.

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Authors and Affiliations

  1. Faculdade de Ciências da Saúde, Universidade de Brasília, Campus Universitário Darcy Ribeiro, s/n, 70910-900, Brasília, DF, Brazil

    Taís Gratieri

  2. School of Pharmaceutical Sciences, University of Geneva and University of Lausanne, 30 Quai Ernest Ansermet, 1211, Geneva, Switzerland

    Taís Gratieri & Yogeshvar N. Kalia

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  1. Taís Gratieri
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  2. Yogeshvar N. Kalia
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Correspondence to Yogeshvar N. Kalia .

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Editors and Affiliations

  1. School of Pharmacy-Faculty of Medicine The Hebrew University of Jerusalem, Jerusalem, Israel

    Abraham J. Domb

  2. Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), Balanagar, Hyderabad, Andhra Pradesh, India

    Wahid Khan

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Gratieri, T., Kalia, Y.N. (2014). Topical Iontophoresis for Targeted Local Drug Delivery to the Eye and Skin. In: Domb, A., Khan, W. (eds) Focal Controlled Drug Delivery. Advances in Delivery Science and Technology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-9434-8_12

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