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Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy pp 157–170Cite as

Mitochondrial Reactive Oxygen Species in Proapoptotic Effect of Promising Cancer Chemopreventive Phytochemicals

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Abstract

Cancer chemopreventive phytochemicals have been identified from multiple dietary plants as well as from components of alternative medicine. Preclinical studies using rodent cancer models have provided compelling experimental evidence for cancer chemopreventive effects of these phytochemicals. Mitochondria-derived reactive oxygen species (ROS) play a critical role in their prodeath and chemopreventive responses. These phytochemicals inhibit mitochondrial electron transport chains causing ROS production, thus triggering apoptotic and/or autophagic cancer cell death. Although normal epithelial cells are resistant to mitochondrial perturbations by many phytochemicals, underlying mechanisms of the differential response in cancer cells versus normal cells remain elusive. This chapter reviews experimental evidence linking mitochondrial reactive oxygen species in cancer chemopreventive effects of a few promising phytochemicals.

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Abbreviations

ITCs:

isothiocyanates

ROS:

reactive oxygen species

MRC:

mitochondrial respiratory chain

PEITC:

phenethyl isothiocyanate

BITC:

benzyl isothiocyanate

SFN:

D,L-sulforaphane

RES:

resveratrol

WA:

withaferin A

MOMP:

mitochondrial outer membrane permeabilization

GSH:

glutathione

OXPHOS:

oxidative phosphorylation

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Acknowledgments

The work cited from the corresponding author’s laboratory was supported in part by the National Cancer Institute of the National Institutes of Health under Award Numbers RO1 CA101753, RO1 CA 115498, RO1 CA129347, and R01 CA142604. The content of this chapter is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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  1. Department of Pharmacology & Chemical Biology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Anuradha Sehrawat & Shivendra V. Singh

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  1. Anuradha Sehrawat
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  2. Shivendra V. Singh
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Correspondence to Shivendra V. Singh .

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  1. Pharmacology and Therapeutics, Roswell Park Cancer Institute Center for Genetics and Pharmacology, Buffalo, New York, USA

    Dhyan Chandra

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Sehrawat, A., Singh, S. (2013). Mitochondrial Reactive Oxygen Species in Proapoptotic Effect of Promising Cancer Chemopreventive Phytochemicals. In: Chandra, D. (eds) Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9326-6_7

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