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Basic and Translational Research on Dietary Phytochemicals and Cancer Prevention

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Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy

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Abstract

Natural or chemically modified dietary phytochemicals are particularly favored for cancer prevention because they can reverse, suppress, or prevent the initial phase of carcinogenesis or the neoplastic cell progression to cancer mass, and therefore, eliminate premalignant and malignant cell populations either in general or in high-risk populations. Screening and identifying dietary phytochemicals for chemoprevention requires in vitro studies of cell lines and animal models before translation into clinical trials. Understanding the molecular pathways that dietary phytochemicals modify could help in designing successful cancer prevention clinical trials. To date, a number of chemoprevention clinical trials have been conducted with limited success. One of the reasons for unsuccessful clinical trials was the lack of a clear molecular target against a particular cancer type. High-throughput screening of phytochemicals to induce premalignant and malignant cell apoptosis by targeting multiple gene pathways should be assessed for future prevention of human cancers.

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Acknowledgments

We thank the Department of Scientific Publications at The University of Texas MD Anderson Cancer Center for editing the manuscript. The original work was supported in part by National Cancer Institute grant R01 CA117895 and by the Duncan Family Institute for Cancer Prevention and Risk Assessment, The University of Texas MD Anderson Cancer Center.

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Authors and Affiliations

  1. Department of Clinical Cancer Prevention, Unit 1360, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., 77030, Houston, TX, USA

    Ashraful Hoque M.D., Ph.D.M.D. & Xiao-Chun Xu M.D., Ph.D.M.D.

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  1. Ashraful Hoque M.D., Ph.D.M.D.
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  2. Xiao-Chun Xu M.D., Ph.D.M.D.
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Editors and Affiliations

  1. Pharmacology and Therapeutics, Roswell Park Cancer Institute Center for Genetics and Pharmacology, Buffalo, New York, USA

    Dhyan Chandra

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Hoque, A., Xu, XC. (2013). Basic and Translational Research on Dietary Phytochemicals and Cancer Prevention. In: Chandra, D. (eds) Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9326-6_6

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