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Targeting Cellular Signaling for Cancer Prevention and Therapy by Phytochemicals

  • Fang Hao
  • Neelu Yadav
  • Dhyan Chandra
Chapter

Abstract

Phytochemicals are plant-derived compounds and have been considered as promising chemopreventive agents for decades. Phytochemicals are broadly classified as carotenoids, phenolics, alkaloids, nitrogen-containing compounds, and organosulfur compounds. These plant-derived compounds modulate the hallmark events in tumorigenesis including the control of cellular redox, cell proliferation and death, angiogenesis, and cell migration. Preclinical studies on a number of phytochemicals in mouse models support anticancer activities of these compounds. Clinical studies of some phytochemicals reveal inconsistency with preclinical findings, thus highlighting the necessity of detailed in vivo analysis of the mechanism of action of these compounds prior to initiate large-scale clinical trials. This chapter describes some of the key molecular cellular signaling that could be targeted to utilize full benefits of these phytochemicals for cancer prevention and therapy.

Keywords

Apoptosis Mitochondria Autophagy Phytochemicals Angiogenesis Cellular redox Reactive oxygen species (ROS) Cell proliferation Cell migration and invasion Lycopene β-Carotene Clinical trials Resveratrol Neem limonoids 

Notes

Acknowledgments

This work was supported in part by the National Cancer Institute of the National Institutes of Health under Award Number R01CA160685 and the American Cancer Society Research Scholar Grant RSG-12-214-01– CCG to DC; and the National Cancer Institute Center Support Grant P30 CA016056 to the Roswell Park Cancer Institute. We apologize to those colleagues whose publications could not be cited due to space constraints.

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© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Pharmacology and TherapeuticsRoswell Park Cancer InstituteBuffaloUSA

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