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OxPhos Defects and Their Role in Cancer Initiation and Progression

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Book cover Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy

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Abstract

This chapter provides a brief overview of the oxidative phosphorylation (OxPhos) carried out by five multimeric enzyme complexes. The biogenesis of the OxPhos system is very complicated because of its dual genetic origin and involvement of a large number of genes, whose products are made at two different locations, the cytosol and mitochondrial matrix. Both genetic and nongenetic factors can cause OxPhos deficiency, which can alter signaling pathways such as p53, AKT, and NF-κB and thereby promote cancer development. A model for tumorigenesis due to OxPhos deficiency is described. This model suggests that functional decline of mitochondria with age may cause p53 suppression and thereby increase the incidence of cancer. Phytochemicals can prevent cancer development by improving OxPhos and by alleviating oxidative/redox stress and chronic inflammation.

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Funding

This work was supported by start-up and translational funds from CEAR at the PVLSI supported by an award (A00000000004448) from Massachusetts Technology Collaborative as administrator of the John Adams Innovation Institute to N.Y. We also thank Seahorse Bioscience Inc. for their in-kind support.

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Authors and Affiliations

  1. Pioneer Valley Life Sciences Institute, 01107, Springfield, MA, USA

    Nagendra Yadava, Ahmed Khalil & Sallie S. Schneider

  2. Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, 01003, USA

    Nagendra Yadava

  3. Department of Biology, University of Massachusetts, 01003, Amherst, MA, USA

    Nagendra Yadava

  4. Department of Veterinary and Animal Sciences, University of Massachusetts, 01003, Amherst, MA, USA

    Sallie S. Schneider

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  1. Nagendra Yadava
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  2. Ahmed Khalil
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Correspondence to Nagendra Yadava .

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  1. Pharmacology and Therapeutics, Roswell Park Cancer Institute Center for Genetics and Pharmacology, Buffalo, New York, USA

    Dhyan Chandra

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Yadava, N., Khalil, A., Schneider, S. (2013). OxPhos Defects and Their Role in Cancer Initiation and Progression. In: Chandra, D. (eds) Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9326-6_1

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