Role of RNAi in Cancer

  • Kewal K. Jain


RNA interference (RNAi) is an ancient natural antiviral mechanism that directs silencing of gene expression in a sequence-specific manner. It is one of the technologies for suppression of gene function of which the best known involves the use of antisense oligonucleotides. RNAi involves the use of a double-stranded RNA (dsRNA). Once in the cell, the dsRNAs are processed into short, 21–23 nucleotide dsRNAs termed small interfering RNAs (siRNAs) that are used in a sequence-specific manner to recognize and destroy complementary RNAs. There are several classes of naturally occurring small RNA species, including siRNAs, repeat-associated siRNAs (rasiRNAs), and microRNAs (miRNAs); the last type is described in Chap. 13. Basics of RNAi and details of RNAi-based therapeutics are described in detail in a special report on this topic (Jain 2013).


Human Papilloma Virus Papillary Thyroid Carcinoma Focal Adhesion Kinase Antisense Oligonucleotide siRNA Delivery 
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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Kewal K. Jain
    • 1
  1. 1.Jain PharmaBiotechBaselSwitzerland

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