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Proteases in Health and Disease pp 79–88Cite as

Microbial Source of Fibrinolytic Protease and Its Biotechnological Potential

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Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 7))

Abstract

Many fibrinolytic proteases are isolated and purified from various sources. These fibrinolytic proteases have biotechnological applications to treat cardiovascular diseases. Fibrinolytic enzyme, Actinokinase is isolated and produced from thermophilic Streptomyces megasporus SD5. The fibrinolytic enzyme is serine endopeptidase. The proteolytic enzyme which acts on different substrates casein, azocasein, fibrin etc. Enzyme is plasminogen independent. Some of these properties are studied & summarized for isolated fibrinolytic protease. Various fibrinolytic proteases also isolated from different resources and their biochemical characterization is reported in the literatures. In general proteases are also used in food, pharmaceutical, cosmetics and environmental industry. Overall all proteases have been used for application prospectives. There are many fibrinolytic proteases discovered till todate. These agents need to check thoroughly to their biochemical properties and substrate base catalysis. Therefore microbial fibrinolytic proteases are used for therapeutic approach of medical interest. The diverse microbial population produces the fibrinolytic proteases. The properties of fibrinolytic enzymes are described in different literatures. Many reported fibrinolytic enzymes are plasminogen activator and some are fibrin specific in nature. These enzymes had drawbacks such as bleeding complications, haemorragic in nature and expensive in nature. So search of new fibrinolytic proteases is still in continued for better molecule.

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Author information

Authors and Affiliations

  1. Microbial Sciences Division, MACS-Agharkar Research Institute, G.G. Agarkar Road, Pune, MS, 411 004, India

    Ratnakar R. Chitte

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  1. Ratnakar R. Chitte
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Correspondence to Ratnakar R. Chitte .

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Editors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Institute of Cardiovascular Sciences, University of Manitoba, St. Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada

    Naranjan S. Dhalla

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Chitte, R.R. (2013). Microbial Source of Fibrinolytic Protease and Its Biotechnological Potential. In: Chakraborti, S., Dhalla, N. (eds) Proteases in Health and Disease. Advances in Biochemistry in Health and Disease, vol 7. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9233-7_6

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