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Escalated Expression of Matrix Metalloproteinases in Osteoarthritis

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Proteases in Health and Disease

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 7))

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Abstract

Osteoarthritis (OA) is a disease that damages the joint tissues and often destroys the cartilage lining of the joint tissue irreversibly. This leads to loss of joint function making movement difficult and crippling the affected individuals. OA primarily affects elderly population and with increasing aging human population in the world it is going to affect a very large portion of the population in the near future. Unfortunately there is no current method of treatment of this disease except by suppressing the pain with pain-killer and occasional use of steroid to reduce excruciating pain. More radical treatment and often the only remaining option is surgery where affected joint tissue is removed and replaced with artificial prosthetics embedded into the bone, a procedure called arthroplasty. The surgical procedure is costly and sometimes associated with recurring post-operative problems. New approaches to control and cure OA could come from a better understanding of the cellular and subcellular events in the joint tissues of OA patients. Since cartilage depletion is a major pathological event in the progression of OA, much attention has been given to the cellular mechanisms responsible for the cartilage damage. This review will address this cellular process by focusing on enzymes which are activated in the cartilage tissue and cause its depletion.

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Authors and Affiliations

  1. Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, 65211, USA

    Srijita Dhar, Bimal K. Ray & Alpana Ray

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  1. Srijita Dhar
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  2. Bimal K. Ray
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  3. Alpana Ray
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Correspondence to Alpana Ray .

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Editors and Affiliations

  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Institute of Cardiovascular Sciences, University of Manitoba, St. Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada

    Naranjan S. Dhalla

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Dhar, S., Ray, B.K., Ray, A. (2013). Escalated Expression of Matrix Metalloproteinases in Osteoarthritis. In: Chakraborti, S., Dhalla, N. (eds) Proteases in Health and Disease. Advances in Biochemistry in Health and Disease, vol 7. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9233-7_18

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