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Role of Proteases During Intra-erythrocytic Developmental Cycle of Human Malaria Parasite Plasmodium falciparum

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Proteases in Health and Disease

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 7))

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Abstract

Malaria remains a major parasitic disease in the tropical and sub-tropical countries mainly due to dramatic increase in parasite lines resistant to commonly used anti-malarials. Characterization of novel metabolic pathways in the parasites and understanding their functional role is a prerequisite to design new anti-malarial strategies. Parasite proteases play key role in growth and differentiation of all the developmental stages across the parasite life cycle and present the most promising targets to develop new drugs against malaria. In Plasmodium falciparum genome database a total of 123 proteases are identified; these proteases belong to five different clans: Cysteine, Aspartic, Serine, Metallo-, and Threonine. Some of the most studied parasite proteases are those that are functional in the asexual blood stage cycle. Starting with the processing of key parasite ligand in merozoite, the invasive form of blood stage parasite, degradation of host hemoglobin in food-vacuole, regulation of levels of key metabolic pathways in cytosol and cellular organelles, degradation of misfolded and unused proteins, and rupture of host membrane for egress of daughter merozoites is mediated by these proteases. Here we discuss roles of some of the parasite proteases involved in various steps of the parasite intra-erythrocytic cycle.

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Acknowledgements

The Malaria Group at ICGEB is supported by Program Support Grant from Department of Biotechnology, Govt. of India, and research grant to AM under Indo-Swiss Joint Research Programme from Department of Science & Technology, Govt. of India. AM is a recipient of National Bioscience Award for Career Development from Department of Biotechnology, Govt. of India.

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  1. International Centre for Genetic Engineering and Biotechnology, New Delhi, 110 067, India

    Sumit Rathore, Shaifali Jain, MohD Asad, Gaurav Datta, Pawan Malhotra & Asif Mohmmed

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  1. Sumit Rathore
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  2. Shaifali Jain
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  3. MohD Asad
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  4. Gaurav Datta
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  5. Pawan Malhotra
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  6. Asif Mohmmed
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Correspondence to Asif Mohmmed .

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  1. Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. Institute of Cardiovascular Sciences, University of Manitoba, St. Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada

    Naranjan S. Dhalla

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Rathore, S., Jain, S., Asad, M., Datta, G., Malhotra, P., Mohmmed, A. (2013). Role of Proteases During Intra-erythrocytic Developmental Cycle of Human Malaria Parasite Plasmodium falciparum . In: Chakraborti, S., Dhalla, N. (eds) Proteases in Health and Disease. Advances in Biochemistry in Health and Disease, vol 7. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9233-7_13

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