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Drug Nanocrystals

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Fundamentals of Pharmaceutical Nanoscience

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Abstract

Drug nanocrystals are nanosized particles, where the solid drug is covered with a stabilizer layer. Their main benefit is faster dissolution, but they are also used for increasing the bioavailability of drugs, which have narrow absorption window or suffer large differences in oral absorption between the fed and fasted states. Drug nanocrystals can be produced either by top-down (e.g., wet milling or high-pressure homogenization) or bottom-up (e.g., antisolvent precipitation) techniques. Compared to other nanotechnological approaches in medicine, drug nanocrystals are considerably simple to produce. Accordingly, pharmaceutical nanocrystals were first time presented in the beginning of the 1990s and already after 10 years the first commercial product was on market. First products were oral tablets, but nanocrystals have been utilized also for ocular, parenteral, dermal, pulmonary, and buccal drug delivery. The main problem with drug nanocrystals is their inherent instability, which can lead to unwanted aggregation, and the selection of a proper stabilizer is crucial for successful nanocrystal formulation.

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Authors and Affiliations

  1. Division of Pharmaceutical Technology, University of Helsinki, Helsinki, Finland

    Leena Peltonen

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  1. Leena Peltonen
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Editors and Affiliations

  1. UCL School of Pharmacy, University College London, London, United Kingdom

    Ijeoma F. Uchegbu

  2. UCL School of Pharmacy, University College London, London, United Kingdom

    Andreas G. Schätzlein

  3. Bexleyheath, United Kingdom

    Woei Ping Cheng

  4. School of Pharmacy & Biomedical Sciences, University of Portsmouth, Portsmouth, United Kingdom

    Aikaterini Lalatsa

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Peltonen, L. (2013). Drug Nanocrystals. In: Uchegbu, I., Schätzlein, A., Cheng, W., Lalatsa, A. (eds) Fundamentals of Pharmaceutical Nanoscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9164-4_11

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