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Live Donor Pancreas Transplantation

  • Miguel Tan
Chapter

Abstract

Live donor pancreas transplantation is a rarely performed operation due to stringent requirements and potential risks to the donor. However, in the context of the difficult-to-transplant, highly sensitized pancreas transplant recipients, living pancreas donation may be an option and should be considered in high-volume centers with the appropriate expertise. The advent of laparoscopic and robotic technology has reduced the morbidity of the donor operation. This chapter discusses inclusion and exclusion criteria for potential donors as well as preoperative workup and outcomes of this highly selected group.

Keywords

Pancreas transplant Live donor Laparoscopic pancreatectomy Segmental pancreas transplant 

References

  1. 1.
    Kennedy WR, Navarro X, Sutherland DE, et al. Neuropathy profile of diabetic patients in a pancreas transplantation program. Neurology. 1995;45(4):773–80.PubMedCrossRefGoogle Scholar
  2. 2.
    Sharara AI, Dandan IS, Khalifeh M et al. Living-related donor transplantation other than kidney. Transplant Proc. 2001;33:2745–6.Google Scholar
  3. 3.
    Gruessner AC, Sutherland DE. Pancreas transplant outcomes for United States (US) and non-US cases as reported to the United Network for Organ Sharing (UNOS) and the International Pancreas Transplant Registry (IPTR) as of October 2002. Clin Transpl. 2002:41–77.Google Scholar
  4. 4.
    Gruessner RW, Leone JP, Sutherland DE, et al. Combined kidney and pancreas transplants from living donors. Transplant Proc. 1998;30:282.PubMedCrossRefGoogle Scholar
  5. 5.
    Gruessner RW, Sutherland DE. Simultaneous kidney and segmental pancreas transplants from living related donors—the first two successful cases. Transplantation. 1996;61:1265–8.PubMedCrossRefGoogle Scholar
  6. 6.
    Gruessner RW. Should priority on the waiting list be given to patients with diabetes: pro. Transplant Proc. 2002;34:1575–6.PubMedCrossRefGoogle Scholar
  7. 7.
    Tan M, Kandaswamy R, Sutherland DE, Gruessner RW, et al. Laparoscopic donor distal pancreatectomy for living donor pancreas and pancreas-kidney transplantation. Am J Transplant. 2005;5(8):1966–70.PubMedCrossRefGoogle Scholar
  8. 8.
    Schweitzer EJ, Wilson J, Jacobs S, Machan CH, Philosophe B, Farney A, et al. Increased rates of donation with laparoscopic donor nephrectomy. Ann Surg. 2000;232(3):392–400.PubMedCrossRefGoogle Scholar
  9. 9.
    Leventhal JR, Deeik RK, Joehl RJ, Rege RV, Herman CH, Fryer JP, et al. Laparoscopic live donor nephrectomy–is it safe? Transplantation. 2000;70(4):602–6.PubMedCrossRefGoogle Scholar
  10. 10.
    Ueno T, Oka M, Nishihara K, Yamamoto K, Nakamura M, Yahara N, et al. Laparoscopic distal pancreatectomy with preservation of the spleen. Surg Laparosc Endosc Percutan Tech. 1999;9(4):290–3.PubMedCrossRefGoogle Scholar
  11. 11.
    Vezakis A, Davides D, Larvin M, McMahon MJ, et al. Laparoscopic surgery combined with preservation of the spleen for distal pancreatic tumors. Surg Endosc. 1999;13(1):26–9.PubMedCrossRefGoogle Scholar
  12. 12.
    Kandaswamy R, Stillman AE, Granger DK, Sutherland DE, Gruessner RW, et al. MRI is superior to angiography for evaluation of living-related simultaneous pancreas and kidney donors. Transplant Proc. 1999;31:604–5.PubMedCrossRefGoogle Scholar
  13. 13.
    Gruessner RW. Living donor pancreas transplantation. In: Gruessner RW, Sutherland DE, Editors. Transplantation of the pancreas. New York:Springer-Verlag; 2004. 423–40.CrossRefGoogle Scholar
  14. 14.
    Tan M, Kandaswamy R, Sutherland DE, Gruessner RW, et al. Laparoscopic donor distal pancreatectomy for living donor pancreas transplantation. Am J Transplant. 2005;5(8):1966–70.PubMedCrossRefGoogle Scholar
  15. 15.
    Troppmann C, Grussner AC, Sutherland DE, Grussner RW, et al. Organ donation by living donors in isolated pancreas and simultaneous pancreas-kidney transplantation. Zentralbl Chir. 1999;124(8):734–8.PubMedGoogle Scholar
  16. 16.
    Gruessner RW, Sutherland DE, Drangstveit MB, Bland BJ, Gruessner AC, et al. Pancreas transplants from living donors: short- and-long-term outcome. Transplant Proc. 2001;33(1–2):819–20.PubMedCrossRefGoogle Scholar
  17. 17.
    Reynoso JF, Gruessner CE, Sutherland DE, Gruessner RW, et al. Short- and long-term outcome for living pancreas donors. J Hepatobiliary Pancreat Sci. 2010;17(2):92–6.PubMedCrossRefGoogle Scholar
  18. 18.
    Humar A, Gruessner RW, Sutherland DE, et al. Living related donor pancreas and pancreas-kidney transplantation. Br Med Bull. 1997;53(4):879–91.PubMedCrossRefGoogle Scholar
  19. 19.
    Kercher KW, Heniford BT, Matthews BD, Smith TI, Lincourt AE, Hayes DH, et al. Laparoscopic versus open nephrectomy in 210 consecutive patients: outcomes, cost, and changes in practice patterns. Surg Endosc. 2003;17(12):1889–95.PubMedCrossRefGoogle Scholar
  20. 20.
    Jacobs SC, Cho E, Foster C, Liao P, Bartlett ST, et al. Laparoscopic donor nephrectomy: the University of Maryland 6-year experience. J Urol. 2004;171(1):47–51.PubMedCrossRefGoogle Scholar
  21. 21.
    International Pancreas Transplant Registry Annual Report. 2002.Google Scholar
  22. 22.
    Sutherland DE, Najarian JS, Gruessner R, et al. Living versus cadaver pancreas transplants. Transplant Proc. 1998;30:2264–6.PubMedCrossRefGoogle Scholar
  23. 23.
    Gruessner RW, Kendall DM, Drangstveit MB, Gruessner AC, Sutherland DE, et al. Simultaneous pancreas-kidney transplantation from live donors. Ann Surg. 1997;226(4):471–82.PubMedCrossRefGoogle Scholar
  24. 24.
    Horgan S, Vanuno D, Benedetti E, et al. Early experience with robotically assisted laparoscopic donor nephrectomy. Surg Laparosc Endosc Percutan Tech. 2002;12(1):64–70.PubMedCrossRefGoogle Scholar
  25. 25.
    Horgan S, Vanuno D, Sileri P, Cicalese L, Benedetti E, et al. Robotic-assisted laparoscopic donor nephrectomy for kidney transplantation. Transplantation. 2002;73(9):1474–9.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Kidney and Pancreas Transplantation, Piedmont Transplant InstitutePiedmont HospitalAtlantaUSA

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