Recombinant Immunotoxins

  • Robert J. Kreitman
Part of the Cancer Drug Discovery and Development book series (CDD&D)


Recombinant immunotoxins contain a recombinant antibody and a protein toxin, capable of killing a cell after internalization and transport of the toxin to the cytosol. Growth factor fusion toxins, including the approved molecule denileukin diftitox, contain a growth factor such as interleukin-2 and truncated toxin. Recombinant immunotoxins furthest along in clinical development are BL22 (CAT-3888) and HA22 (CAT-8015 or moxetumomab pasudotox) targeting CD22 and LMB-2 targeting CD25. These agents have induced complete and partial responses in patients with chemoresistant hairy cell leukemia (HCL) and partial responses with other hematologic malignancies. Clinical development is continuing with these and other agents for different forms of cancer.


Monoclonal antibody Fusion toxin CD22 CD25 Diphtheria toxin Pseudomonas exotoxin Ricin KDEL receptor Fv Chronic lymphocytic leukemia Hairy cell leukemia Adult T-cell leukemia SS1P CD19 Mesothelin CD3 



The work regarding LMB-2, BL22, HA22, and SS1P was in part supported by the intramural program, NCI. Clinical development regarding BL22 and HA22 was in part funded by MedImmune, LLC.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Laboratory of Molecular BiologyNational Cancer Institute, National Institutes of HealthBethesdaUSA

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