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Drug Interactions

  • Laurent P. Rivory
Chapter
Part of the Cancer Drug Discovery and Development book series (CDD&D)

Abstract

Drug–drug interactions in cancer patients are relatively common and can and do have significant impact on outcomes. Increasingly, it is being recognized that these arise through the complex interplay of drugs with both metabolic and transport processes. The complexity is increased through the time lags that may occur between the administration of interacting drugs, the fact that some drugs can both induce and inhibit metabolism, and the inhibition of multiple pathways by some. The potential for drug–drug interaction needs to be considered in the development of new drugs as well as in the routine use of existing agents.

Keywords

drug-drug interactions Drug metabolism Drug disposition Transporters 

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© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Faculty of ScienceThe University of New South WalesSydneyAustralia

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