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Handbook of Anticancer Pharmacokinetics and Pharmacodynamics pp 351–371Cite as

Drug Interactions

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Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

Drug–drug interactions in cancer patients are relatively common and can and do have significant impact on outcomes. Increasingly, it is being recognized that these arise through the complex interplay of drugs with both metabolic and transport processes. The complexity is increased through the time lags that may occur between the administration of interacting drugs, the fact that some drugs can both induce and inhibit metabolism, and the inhibition of multiple pathways by some. The potential for drug–drug interaction needs to be considered in the development of new drugs as well as in the routine use of existing agents.

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  1. Faculty of Science, The University of New South Wales, Sydney, NSW, 2052, Australia

    Laurent P. Rivory Ph.D.

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  1. Sidney Kimmel Comprehensive Cancer Cente, Baltimore, Maryland, USA

    Michelle A. Rudek

  2. Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA

    Cindy H. Chau

  3. Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA

    William D. Figg

  4. Moffitt Cancer Center, Tampa, Florida, USA

    Howard L. McLeod

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Rivory, L.P. (2014). Drug Interactions. In: Rudek, M., Chau, C., Figg, W., McLeod, H. (eds) Handbook of Anticancer Pharmacokinetics and Pharmacodynamics. Cancer Drug Discovery and Development. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9135-4_19

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