White Matter Repair in Subcortical Stroke

Chapter
Part of the Springer Series in Translational Stroke Research book series (SSTSR, volume 4)

Abstract

White matter stroke is a common clinical problem, which leads to distinct histological changes that are different than immune-mediated demyelination. The temporal changes occurring in white matter stroke such as acute loss of axons and astrocytic and microglia responses are likely to change the milieu of the stroke white matter into an inhibitory environment to the remyelination process. Based on the limited number of studies investigating acute and chronic injury states of demyelination, it is yet unclear if a window of opportunity exists after white matter stroke to enhance white matter repair. Although stroke-specific inhibitory mechanisms are not well known, a comprehensive list of pro- and anti-remyelination factors derived from non-stroke white matter diseases is in place to guide further investigation.

Keywords

Migration Ischemia Tyrosine Leukemia Integrin 

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© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of NeurologyUniversity of California, Los AngelesLos AngelesUSA

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