Drug Delivery in the Context of Stroke and Brain Trauma

  • Richard F. Keep
  • Jianming Xiang
  • Ningna Zhou
  • Anuska V. Andjelkovic
Part of the AAPS Advances in the Pharmaceutical Sciences Series book series (AAPS, volume 10)


Stroke and traumatic brain injury (TBI) cause marked changes in blood–brain barrier (BBB) function. These changes result in increased barrier permeability, vasogenic edema, and an influx of leukocytes into brain. As such, they are a therapeutic target. In addition, changes at the BBB can affect the entry of therapeutics into the brain. This chapter describes the changes in BBB function that occur after brain injury, the impact on drug delivery for stroke and TBI and potential ways of circumventing the BBB for therapy.


Traumatic Brain Injury Cerebral Ischemia Cerebral Endothelium Tight Junction Structure Small Molecular Weight Compound 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


ABC transporters

ATP-binding cassette transporters


Blood–brain barrier


Brain-derived neurotrophic factor


Basic fibroblast growth factor


Cerebrospinal fluid


Intracerebral hemorrhage


Intraventricular hemorrhage




Subarachnoid hemorrhage


Na-dependent Vitamin C Transporter 2


Traumatic brain injury


Tight junction


Tissue plasminogen activator



This study was supported by grants NS-034709 (RFK), NS 062853 (AVA), and NS075757 (AVA) from the National Institutes of Health (NIH) and a grant from the Motor City Golf Classic (JX). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.


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Copyright information

© American Association of Pharmaceutical Scientists 2014

Authors and Affiliations

  • Richard F. Keep
    • 1
    • 2
  • Jianming Xiang
    • 2
  • Ningna Zhou
    • 2
  • Anuska V. Andjelkovic
    • 2
    • 3
  1. 1.Department of Molecular and Integrative Physiology, R5018 Biomedical Science Research BuildingUniversity of MichiganAnn ArborUSA
  2. 2.Department of Neurosurgery, R5018 Biomedical Science Research BuildingUniversity of MichiganAnn ArborUSA
  3. 3.Department of Pathology, R5018 Biomedical Science Research BuildingUniversity of MichiganAnn ArborUSA

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