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Drug Delivery in the Context of Stroke and Brain Trauma

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Book cover Drug Delivery to the Brain

Part of the book series: AAPS Advances in the Pharmaceutical Sciences Series ((AAPS,volume 10))

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Abstract

Stroke and traumatic brain injury (TBI) cause marked changes in blood–brain barrier (BBB) function. These changes result in increased barrier permeability, vasogenic edema, and an influx of leukocytes into brain. As such, they are a therapeutic target. In addition, changes at the BBB can affect the entry of therapeutics into the brain. This chapter describes the changes in BBB function that occur after brain injury, the impact on drug delivery for stroke and TBI and potential ways of circumventing the BBB for therapy.

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Abbreviations

ABC transporters:

ATP-binding cassette transporters

BBB:

Blood–brain barrier

BDNF:

Brain-derived neurotrophic factor

bFGF:

Basic fibroblast growth factor

CSF:

Cerebrospinal fluid

ICH:

Intracerebral hemorrhage

IVH:

Intraventricular hemorrhage

KO:

Knockout

SAH:

Subarachnoid hemorrhage

SVCT2:

Na-dependent Vitamin C Transporter 2

TBI:

Traumatic brain injury

TJ:

Tight junction

tPA:

Tissue plasminogen activator

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Acknowledgments

This study was supported by grants NS-034709 (RFK), NS 062853 (AVA), and NS075757 (AVA) from the National Institutes of Health (NIH) and a grant from the Motor City Golf Classic (JX). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

Author information

Authors and Affiliations

  1. Department of Molecular and Integrative Physiology, R5018 Biomedical Science Research Building, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA

    Richard F. Keep Ph.D.

  2. Department of Neurosurgery, R5018 Biomedical Science Research Building, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA

    Richard F. Keep Ph.D., Jianming Xiang, Ningna Zhou & Anuska V. Andjelkovic

  3. Department of Pathology, R5018 Biomedical Science Research Building, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA

    Anuska V. Andjelkovic

Authors
  1. Richard F. Keep Ph.D.
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  2. Jianming Xiang
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  3. Ningna Zhou
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  4. Anuska V. Andjelkovic
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Corresponding author

Correspondence to Richard F. Keep Ph.D. .

Editor information

Editors and Affiliations

  1. Pharmaceutical Biosciences, Uppsala University Pharmacokinetics and Drug Therapy, Uppsala, Sweden

    Margareta Hammarlund-Udenaes

  2. LACDR/Pharmacology, Leiden University, Leiden, The Netherlands

    Elizabeth C.M. de Lange

  3. Pharmaceutical Sciences Division, University of Wisconsin-Madison School of Pharmacy, Madison, Wisconsin, USA

    Robert G. Thorne

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© 2014 American Association of Pharmaceutical Scientists

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Keep, R.F., Xiang, J., Zhou, N., Andjelkovic, A.V. (2014). Drug Delivery in the Context of Stroke and Brain Trauma. In: Hammarlund-Udenaes, M., de Lange, E., Thorne, R. (eds) Drug Delivery to the Brain. AAPS Advances in the Pharmaceutical Sciences Series, vol 10. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9105-7_23

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