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Methods for Human Sleep Deprivation Experiments

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Sleep Deprivation and Disease

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Abstract

One approach to understanding the importance of sleep in human function involves experimental manipulation of the duration and timing of sleep opportunities. The impact of sleep deprivation (extended wake episodes) and sleep restriction (multiple short sleep episodes) can inform how sleep contributes to normal physiology, cognition, mood, and performance. Here we review common techniques involved in human sleep loss experiments conducted in an inpatient setting. We also discuss important considerations for interpreting the results of inpatient sleep experiments.

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References

  1. Cohen DA, Wang W, Wyatt JK, Kronauer RE, Dijk DJ, Czeisler CA, et al. Uncovering residual effects of chronic sleep loss on human performance. Sci Transl Med. 2010;2(14):14ra13.

    Article  Google Scholar 

  2. Aeschbach D, Matthews JR, Postolache TT, Jackson MA, Giesen HA, Wehr TA. Dynamics of the human EEG during prolonged wakefulness: evidence for frequency-specific circadian and homeostatic influences. Neurosci Lett. 1997;239(2–3):121–4.

    Article  PubMed  CAS  Google Scholar 

  3. Cajochen C, Wyatt JK, Czeisler CA, Bonikowska M, Dijk DJ. Non-linear interaction between the circadian and homeostatic modulation of slow eye movements (SEMs) during wakefulness in humans. J Sleep Res. 2000;9:58.

    Google Scholar 

  4. Pavlova MK, Duffy JF, Shea SA. Polysomnographic respiratory abnormalities in asymptomatic individuals. Sleep. 2008;31(2):241–8.

    PubMed  Google Scholar 

  5. Bianchi MT, Wang W, Klerman E. Sleep misperception in healthy adults: implications for insomnia diagnosis. J Clin Sleep Med. 2012;8(5):547–54.

    PubMed  Google Scholar 

  6. Harvey AG, Tang NK. (Mis)perception of sleep in insomnia: a puzzle and a resolution. Psychol Bull. 2012;138(1):77–101.

    Article  PubMed  Google Scholar 

  7. Van Dongen HPA, Baynard MD, Maislin G, Dinges DF. Systematic interindividual differences in neurobehavioral impairment from sleep loss: evidence of trait-like differential vulnerability. Sleep. 2004;27:423–33.

    PubMed  Google Scholar 

  8. Leproult R, Colecchia EF, Berardi AM, Stickgold R, Kosslyn SM, Van Cauter E. Individual differences in subjective and objective alertness during sleep deprivation are stable and unrelated. Am J Physiol Regul Integr Comp Physiol. 2003;284:R280–90.

    PubMed  CAS  Google Scholar 

  9. Frey DJ, Badia P, Wright Jr KP. Inter- and intra-individual variability in performance near the circadian nadir during sleep deprivation. J Sleep Res. 2004;13(4):305–15.

    Article  PubMed  Google Scholar 

  10. Iber C, Ancoli-Israel S, Chesson A, Quan SF. The AASM manual for the scoring of sleep and associated events: rules, terminology and technical specifications, vol. 1. Westchester, IL: American Academy of Sleep Medicine; 2007.

    Google Scholar 

  11. Cajochen C, Wyatt JK, Czeisler CA, Dijk DJ. Separation of circadian and wake duration-dependent modulation of EEG activation during wakefulness. Neuroscience. 2002;114(4):1047–60.

    Article  PubMed  CAS  Google Scholar 

  12. Kunz MA. Estimation of sleep and wake from wrist actigraphy: a validation study using sleep and wake quantified from ambulatory polysomnography [dissertation]. Boston, MA: Boston University; 2004.

    Google Scholar 

  13. Kushida CA, Chang A, Gadkary C, Guilleminault C, Carrillo O, Dement WC. Comparison of actigraphic, polysomnographic, and subjective assessment of sleep parameters in sleep-disordered patients. Sleep Med. 2001;2:389–96.

    Article  PubMed  CAS  Google Scholar 

  14. Natale V, Plazzi G, Martoni M. Actigraphy in the assessment of insomnia: a quantitative approach. Sleep. 2009;32(6):767–71.

    PubMed  Google Scholar 

  15. Ancoli-Israel S, Cole R, Alessi C, Chambers M, Moorcroft W, Pollak CP. The role of actigraphy in the study of sleep and circadian rhythms. Sleep. 2003;26(3):342–92.

    PubMed  Google Scholar 

  16. Stone KL, Ancoli-Israel S. Actigraphy. In: Kryger MH, Roth T, Dement WC, editors. Principles and practices of sleep medicine, vol. 5. Philadelphia, PA: Elsevier; 2010. p. 1668–75.

    Google Scholar 

  17. Klerman EB, Lee Y, Czeisler CA, Kronauer RE. Linear demasking techniques are unreliable for estimating the circadian phase of ambulatory temperature data. J Biol Rhythms. 1999;14(4):260–74.

    Article  PubMed  CAS  Google Scholar 

  18. Chang A, Aeschbach D, Duffy JF, Czeisler CA. Impact of evening use of light-emitting electronic readers on circadian timing and sleep latency. Sleep. 2012;35:A206.

    Google Scholar 

  19. Duffy JF, Czeisler CA. Effect of light on human circadian physiology. Sleep Med Clin. 2009;4:165–77.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Division of Sleep Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Elizabeth B. Klerman M.D., Ph.D.

  2. Division of Sleep Medicine, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA

    Matt T. Bianchi M.D., Ph.D., M.M.Sc.

Authors
  1. Elizabeth B. Klerman M.D., Ph.D.
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  2. Matt T. Bianchi M.D., Ph.D., M.M.Sc.
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Corresponding author

Correspondence to Matt T. Bianchi M.D., Ph.D., M.M.Sc. .

Editor information

Editors and Affiliations

  1. Department of Neurology Sleep Division, Harvard Medical School Massachusetts General Hospital, Boston, Massachusetts, USA

    Matt T. Bianchi

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Klerman, E.B., Bianchi, M.T. (2014). Methods for Human Sleep Deprivation Experiments. In: Bianchi, M. (eds) Sleep Deprivation and Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9087-6_3

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  • DOI: https://doi.org/10.1007/978-1-4614-9087-6_3

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-9086-9

  • Online ISBN: 978-1-4614-9087-6

  • eBook Packages: MedicineMedicine (R0)

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