Advertisement

Diuretics

  • Alluru S. ReddiEmail author
Chapter

Abstract

Diuretics promote Na+ and water excretion. Excretion of Na+ in the urine is called natriuresis, whereas diuresis refers to increased urine flow rate. In clinical medicine, two types of diuresis are recognized: solute diuresis and water diuresis. Solute diuresis results from a decrease in the renal tubular reabsorption of solute. Since water reabsorption follows solute reabsorption, inhibition of solute reabsorption generally diminishes water transport. However, water diuresis can be promoted without solute diuresis by drugs, which impair the action of antidiuretic hormone (ADH). Examples include ADH receptor blockers (vaptans) and lithium. This chapter reviews briefly the various groups of diuretics, their physiologic action, clinical use, and complications.

Keywords

Diuretics Natriuresis Diuresis 

Suggested Reading

  1. 1.
    Ellison DH, Hoorn EJ, Wilcox CJ. Diuretics. In: Taal MW, Chertow GM, Marsden PA, et al., editors. Brenner and Rector’s The kidney (9th ed). Philadelphia: Elsevier Saunders; 2012. pp. 1879–916.Google Scholar
  2. 2.
    Reddy P, Mooradian AD. Diuretics: an update on the pharmacology and clinical uses. Am J Ther. 2009;16:74–85.PubMedCrossRefGoogle Scholar
  3. 3.
    Seldin D, Giebisch G, editors. Diuretic agents. Clinical physiology and pharmacology. San Diego: Academic; 1997.Google Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of Medicine Division of Nephrology and HypertensionRutgers New Jersey Medical SchoolNewarkUSA

Personalised recommendations