Renal Handling of NaCl and Water
The kidneys filter about 180 L of plasma daily. Most of this plasma must be reclaimed in order to maintain fluid and electrolyte homeostasis. The protein-free ultrafiltrate is modified in composition as it passes through various segments of the nephron to form urine. Sodium (Na+) and its anion chloride (Cl−) are the major determinants of the extracellular fluid (ECF) volume and both ions are effectively reabsorbed. Water reabsorption follows Na+ reabsorption in order to maintain normal osmolality in the ECF compartment. The proximal tubule is the major site of reclamation, whereas the other segments reclaim to a variable degree.
KeywordsNaCl handling in the kidneys Kidneys and NaCl Extracellular fluid volume Renal filtering of NaCl Proximal tubule function Na+ reabsorption in kidneys
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