Abstract
In the previous chapter, we presented various causes of high anion gap (AG) metabolic acidosis. For discussion purpose, these causes can be conveniently divided into the following categories: acidosis due to kidney injury; acidosis due to accumulation of organic acids; and acidosis due to toxins. Metabolic acidosis affects almost all organ systems; however, the following are the most important clinical manifestations: cardiovascular, neurologic, and respiratory.
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References
Barceloux DG, Krenzelok EP, Olson K, et al. American academy of clinical toxicology practice guidelines on the treatment of ethylene glycol poisoning. J Toxicol Clin Toxicol. 1999;37:537–60.
Suggested Reading
Cerdá J, Tolwani AJ, Warnock DG. Critical care nephrology: management of acid-base disorders with CRRT. Kidney Int. 2012;82:9–18.
Fall PJ, Szerlip HM. Lactic acidosis: from sour milk to septic shock. J Intensive Care Med. 2005;20:255–71.
Fenves AZ, Kirkpatrick HM III, Patel VV, et al. Increased anion gap metabolic acidosis as a result of 5-oxoproline (pyroglutamic acid): a role for acetaminophen. Clin J Am Soc Nephrol. 2006;1:441–7.
Kraut JA, Madias NE. Treatment of acute metabolic acidosis: a pathophysiologic approach. Nat Rev Nephrol. 2012;8:589–601.
Kraut JA, Xing SX. Approach to the evaluation of a patient with an increased serum osmolal gap and high-anion gap metabolic acidosis. Am J Kidney Dis. 2011;58:480–4.
Kraut JA, Madias NE. Metabolic acidosis: pathophysiology, diagnosis and management. Nat Rev Nephrol. 2010;6:274–85.
Hood Vl. Lactic acidosis. In: Jennari FJ, Adrogué HJ, Galla JH, Madias NE, editors. Acid-base disorders and their treatment. Boca Raton: Taylor & Francis; 2005. pp 351–82.
Laski ME, Wesson DE. Lactic acidosis. In: Acid-base and electrolyte disorders. A companion to Brenner & Rector’s the Kidney. Philadelphia: Saunders; 2002. pp 83–107.
Velez JC, Janech MG. A case of lactic acidosis induced by linezolid. Nat Rev Nephrol. 2010;6:236–40.
Kang KP, Lee S, Kang SK. D-Lactic acidosis in humans: review of update. Electrolyte Blood Press. 2006;4:53–6.
Oh MS, Halperin ML. Toxin-induced metabolic acidosis. In: Jennari FJ, Adrogué HJ, Galla JH, Madias NE, editors. Acid-base disorders and their treatment. Boca Raton: Taylor & Francis; 2005, pp 383–415.
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Reddi, A. (2014). High Anion Gap Metabolic Acidosis. In: Fluid, Electrolyte and Acid-Base Disorders. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9083-8_28
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DOI: https://doi.org/10.1007/978-1-4614-9083-8_28
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