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Mechanisms of Liver Injury

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Diseases of the Liver in Children

Abstract

A diverse range of pathophysiologic processes lead to liver injury in the pediatric population. This chapter discusses mechanisms of hepatocyte or other liver cellular injury, beginning with a brief discussion of liver functions and general mechanisms of cell death. Particular attention is paid to the role of apoptotic pathways and mitochondrial damage in liver diseases, including metabolic disorders, infections, toxin ingestions, and diseases that primarily affect the biliary tree.

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Author information

Authors and Affiliations

  1. Division of Pediatric Surgery, Department of Surgery, University of Washington School of Medicine, Seattle Children’s Hospital, 4800 Sand Point Way, W-7729, Seattle, WA, 98105, USA

    Kimberly J. Riehle MD

  2. Department of Pathology, University of Washington, 4800 Sand Point Way, W-7729, Seattle, WA, 98105, USA

    Nelson Fausto MD

Authors
  1. Kimberly J. Riehle MD
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  2. Nelson Fausto MD
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Corresponding author

Correspondence to Kimberly J. Riehle MD .

Editor information

Editors and Affiliations

  1. University of Washington School of Medicine, Seattle Children’s Hospital, Seattle, Washington, USA

    Karen F. Murray

  2. University of Washington School of Medicine, Seattle Children’s Hospital, Seattle, Washington, USA

    Simon Horslen

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Riehle, K.J., Fausto, N. (2014). Mechanisms of Liver Injury. In: Murray, K., Horslen, S. (eds) Diseases of the Liver in Children. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9005-0_4

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  • DOI: https://doi.org/10.1007/978-1-4614-9005-0_4

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