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Liver in Systemic Disease

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Diseases of the Liver in Children

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Abstract

As a major component of the body’s filtration system and metabolic machinery, the liver is affected in many systemic diseases. Systemic diseases that manifest primarily in the liver, or with accompanying liver disease as one of the most common manifestations, have been discussed elsewhere in the text. However, hepatitis, cholestasis, or other liver disease may be secondary manifestations of many other systemic diseases. The pediatric hepatologist is often consulted to interpret liver abnormalities in children with other systemic diseases. This chapter provides an overview of the liver involvement characteristic of major systemic diseases, by organ system.

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Abbreviations

6-MP:

6-mercaptopurine

AIH:

Autoimmune hepatitis

ALP:

Alkaline phosphatase

ALT:

Alanine aminotransferase

AST:

Aspartate aminotransferase

CGD:

Chronic granulomatous disease

DIC:

Disseminated intravascular coagulation

GGT:

Gamma-glutamyl transferase

GVHD:

Graft-versus-host disease

HLH:

Hemophagocytic lymphohistiocytosis

IVC:

Inferior vena cava

IVIG:

Intravenous immunoglobulin

JIA:

Juvenile idiopathic arthritis

LDH:

Lactate dehydrogenase

MAS:

Macrophage activation syndrome

NAFLD:

Nonalcoholic fatty liver disease

NSAIDs:

Nonsteroidal anti-inflammatory drugs

PAN:

Polyarteritis nodosa

PBC:

Primary biliary cirrhosis

PCR:

Polymerase chain reaction

PSC:

Primary sclerosing cholangitis

SCT:

Stem cell transplantation

SLE:

Systemic lupus erythematosus

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Authors and Affiliations

  1. Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Francisco, 500 Parnassus Avenue, MU408E, 0136, San Francisco, CA, 94143, USA

    Emily Rothbaum Perito MD, MAS & Philip Rosenthal MD

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  1. Emily Rothbaum Perito MD, MAS
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  2. Philip Rosenthal MD
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Correspondence to Philip Rosenthal MD .

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Editors and Affiliations

  1. University of Washington School of Medicine, Seattle Children’s Hospital, Seattle, Washington, USA

    Karen F. Murray

  2. University of Washington School of Medicine, Seattle Children’s Hospital, Seattle, Washington, USA

    Simon Horslen

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Perito, E.R., Rosenthal, P. (2014). Liver in Systemic Disease. In: Murray, K., Horslen, S. (eds) Diseases of the Liver in Children. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9005-0_29

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  • DOI: https://doi.org/10.1007/978-1-4614-9005-0_29

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