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Acute Liver Failure

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Diseases of the Liver in Children

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Abstract

Pediatric acute liver failure (PALF) is a rare and devastating clinical condition. PALF can be rapidly progressive, and early referral to a pediatric liver transplant center will optimize outcome by providing the child access to all treatment options. The etiologies of PALF differ significantly from adults and also among children at different ages, but an etiology cannot be identified in many children. Those children with an indeterminate diagnosis are more likely to receive a liver transplant than those with an established diagnosis. This chapter highlights the multisystem involvement in PALF. An age-based diagnostic prioritization is presented to facilitate an early diagnosis which may be amenable to specific therapy. Management requires collaborative care, and recommendations are provided for multisystem support.

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  1. Department of Pediatrics, University of Pittsburgh, Children’s Hospital of Pittsburgh of UPMC, Faculty Office Building, Room 6116 4401 Penn Ave, Pittsburgh, PA, 15224, USA

    Robert H. Squires MD

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  1. University of Washington School of Medicine, Seattle Children’s Hospital, Seattle, Washington, USA

    Karen F. Murray

  2. University of Washington School of Medicine, Seattle Children’s Hospital, Seattle, Washington, USA

    Simon Horslen

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Squires, R.H. (2014). Acute Liver Failure. In: Murray, K., Horslen, S. (eds) Diseases of the Liver in Children. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9005-0_23

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