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From Combinatorial Display Techniques to Microarray Technology: New Approaches to the Development and Toxicological Profiling of Targeted Nanomedicines

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Nanotoxicology

Part of the book series: Nanomedicine and Nanotoxicology ((NANOMED))

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Abstract

Advances in genome scale analysis provide an alternative tool to combine large-scale screening of chemicals with detailed mechanistic studies, in which expression signatures for specific factors can be used as predictors of response or serve as new therapeutic targets in vitro and in vivo. Recently, the possibility of analyzing the effects of nanomaterials on a large number of genes has led to toxicogenomic studies in nanotechnology. Furthermore, expression signatures are providing potential targets for the design of ligand-mediated tumor targeting. In this respect, the integration of phage display technique with nanotechnology has been explored as a new approach to generate cancer-targeted nanomedicines. In this chapter we outline advances in microarray technology and in the selection of peptides and antibodies by display techniques. Furthermore, we add insights into their application in the field of toxicogenomics and in the development of targeted nanomedicines.

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Acknowledgments

Our research in this field is supported by the government agencies Fundação de Amparo à pesquisa do Estado de São Paulo (FAPESP), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), and Brazilian Network on Nanotoxicology (MCTI/CNPq).

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Authors and Affiliations

  1. Departamento de Bioquímica (Campus São Paulo) and Departamento de Ciências Biológicas (Campus Diadema), Universidade Federal de São Paulo, Três de Maio, 100, São Paulo, São Paulo, 04044-020, Brazil

    Giselle Z. Justo

  2. Departamento de Bioquímica (Campus São Paulo), Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil

    Eloah R. Suarez, Carina Melo, Marcelo A. Lima & Helena B. Nader

  3. Department of Structural and Chemical Biology,, University of Liverpool, Liverpool, UK

    Marcelo A. Lima

  4. Departamento de Bioquímica (Campus São Paulo), Universidade Federal de São Paulo, Três de Maio, 100, São Paulo, São Paulo, 04044-020, Brazil

    Maria Aparecida S. Pinhal

Authors
  1. Giselle Z. Justo
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  2. Eloah R. Suarez
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  3. Carina Melo
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  4. Marcelo A. Lima
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  5. Helena B. Nader
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  6. Maria Aparecida S. Pinhal
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Corresponding authors

Correspondence to Giselle Z. Justo or Maria Aparecida S. Pinhal .

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Editors and Affiliations

  1. Institute of Chemistry, Universidade Estadual de Campinas—UNICAMP, Campinas, São Paulo, Brazil

    Nelson Durán

  2. Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

    Silvia S. Guterres

  3. Institute of Chemistry, Universidade Estadual de Campinas—UNICAMP, Campinas, São Paulo, Brazil

    Oswaldo L. Alves

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Justo, G.Z., Suarez, E.R., Melo, C., Lima, M.A., Nader, H.B., Pinhal, M.A.S. (2014). From Combinatorial Display Techniques to Microarray Technology: New Approaches to the Development and Toxicological Profiling of Targeted Nanomedicines. In: Durán, N., Guterres, S., Alves, O. (eds) Nanotoxicology. Nanomedicine and Nanotoxicology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8993-1_7

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