In Vitro Cytotoxicity Assays of Nanoparticles on Different Cell Lines
One of the greatest interests in the pharmaceutical and cosmetic industries today is the promising of new substances without adverse effects. Preclinical animal safety investigations and clinical trials increase the time necessary to bring a new candidate compound to the market and increase development costs and time dispensed in this process. Cell culture models are adequate for screening toxicity of several substances including nanomaterials. The data from those models can provide an indication of the safety use of these particles in humans since they are proven hazardous.
KeywordsAutophagic Cell Death Trypan Blue Exclusion Test Lysosome Membrane Permeabilization Standard Cell Line Primary Alveolar Macrophage
Supports from FAPESP, CNPq, INOMAT (MCTI/CNPq), NanoBioss (MCTI), and Brazilian Network on Nanotoxicology (MCTI/CNPq) are acknowledged.
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