One of the most important jobs as an anesthesiologist is to reduce the incidence of adverse perioperative outcome and reduce the incidence of morbidity and mortality associated with various surgeries. Historically, this has been done through applying various medical therapies perioperatively and even postoperatively. Searching for the best therapies is a constant, ongoing pursuit to better the field of anesthesiology. Two huge examples of this ongoing pursuit to find medical therapies to reduce morbidity and mortality in the perioperative period include the use of pre-incision prophylactic antibiotics and perioperative beta-blockade. Another huge modality that is gaining interest is the use of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, also known as statins, as well as other lipid-lowering drugs.
KeywordsCholesterol Angiotensin Warfarin Cyclosporine Aspergillus
The editors and publisher would like to thank Drs. Alan Kaye and Phillip Kalarickal for contributing to the chapter on this topic in the prior edition. It has served as the foundation for the chapter.
- 1.Mahley RW, Bersot TP. Chapter 35: Drug therapy for hypercholesterolemia and dyslipidemia. In: Brunton LL, Lazo JS, Parker KL, editors. Goodman & Gilman’s The pharmacological basis of therapeutics, 11th ed. New York: McGraw-Hill; 2006.Google Scholar
- 3.Katzung BG, Masters SB, Trevor AJ. Basic and clinical pharmacology. 11th ed. New York: McGraw-Hill companies; 2009.Google Scholar
- 15.Rossi S, editor. Australian medicines handbook 2006. Adelaide: Australian Medicines Handbook; 2006.Google Scholar
- 26.Third Report of the National Cholesterol Education Program (NCEP). Expert panel on detection evaluation and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report. Circulation. 2002;106:3143–421.Google Scholar
- 28.Fleisher LA, Beckman JA, Brown KA, et al. ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery. A report of the American college of cardiology/American heart association task force on practice guidelines. Circulation. 2007;116:e418–99.PubMedCrossRefGoogle Scholar
- 30.National Confidential Enquiry into Patient Outcome and Death. Report-abdominal aortic aneurysm: a service in need of surgery? London: NCEPOD; 2005. http://www.ncepod.org.uk/2005report2/Downloads/AAA_report.doc2005.
- 33.American Heart Association. Cardiovascular disease statistics. 2006. Available at: http://www.americanheart.org/presenter.jhtml?identifier=4478.
- 34.British Heart Foundation statistics website. CVD mortality in Europe. 2005. Available at: http://www.heartstats.org/topic.asp?id=753.