Though initially described by Alexander Fleming in the 1940s, there has only been a recent understanding of the development of antibacterial resistance and the role that is played by widespread antimicrobial overuse. This has spurred the development of new antimicrobials and mechanisms by which to counter microbial growth, which unfortunately has plateaued. As a result, special vigilance must now be paid to the appropriate use and timing of antimicrobials in an effort to maintain their efficacy.
KeywordsClavulanic Acid Sputum Culture Positive Sputum Culture Surgical Antimicrobial Prophylaxis Surgical Antibiotic Prophylaxis
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