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Antipyretics: Acetaminophen, Arachidonic Acid Agents, and COX1 and COX2 Inhibitors

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Essentials of Pharmacology for Anesthesia, Pain Medicine, and Critical Care

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Abstract

This chapter is intended to provide an overview of fundamentals of nonsteroidal anti-inflammatory drugs (NSAIDs). They are one of the most commonly prescribed medications, with an estimated 70 million number of prescriptions written annually written and $6.8 billion spent worldwide.

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References

  1. Warner TD, Giuliano F, Vojnovic I, Bukasa A, Mitchell JA, Vane JR. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc Natl Acad Sci U S A. 1999;96:7563–8.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  2. Bleumink GS, Feenstra J, Sturkenboom MC, Stricker BH. Nonsteroidal anti-inflammatory drugs and heart failure. Drugs. 2003;63:525–34.

    Article  CAS  PubMed  Google Scholar 

  3. Rathmell JP, Fields HL. Chapter 11. Pain: pathophysiology and management. In: Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL, Loscalzo J, editors. Harrison’s principles of internal medicine. 18th ed. New York: McGraw-Hill; 2012. http://www.accessmedicine.com/content.aspx?aID=9094544. Accessed 12 Mar 2013.

    Google Scholar 

  4. Grosser T, Smyth E, FitzGerald GA. Goodman & Gilman’s the pharmacological basis of therapeutics, 12e. Section IV. Inflammation, immunomodulation, and hematopoiesis. Chapter 34. Anti-inflammatory, antipyretic, and analgesic agents; pharmacotherapy of gout. New York: McGraw-Hill Education, LLC; 2011.

    Google Scholar 

  5. Thorsteinsson SB, Sigvaldason H, Einarsdottir R, et al. Rofecoxib, but not celecoxib, increases the risk of thromboembolic cardiovascular events in young adults-a nationwide registry-based study. Eur J Clin Pharmacol. 2010;66(6):619–25. doi:10.1007/s00228-010-0789-2. Epub 2010 Feb 16. Gudbjornsson Source Centre for Rheumatology Research, Landspitali University Hospital, Reykjavik, Iceland. bjorngu@landspitali.is.

    Article  PubMed  Google Scholar 

  6. Raju N, Sobieraj-Tieague M, Hirsh J, et al. Effect of aspirin on mortality in the primary prevention of cardiovascular disease. MsCc haematology unit, Queensland Pathology and Department of Internal Medicine, Prince Charles Hospital, Brisbane, Australia SA Pathology, Flinders Medical Centre, Adelaide, Australia Thrombosis Medicine, McMaster University, Hamilton.

    Google Scholar 

  7. Furst DE, Ulrich RW, Prakash S. Chapter 36. Nonsteroidal anti-inflammatory drugs, disease-modifying antirheumatic drugs, nonopioid analgesics, & drugs used in gout. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic & clinical pharmacology. 12th ed. New York: McGraw-Hill; 2012. http://www.accessmedicine.com/content.aspx?aID=55827134. Accessed 12 Mar 2013.

    Google Scholar 

  8. Wyatt JE, Pettit J, Harirforoosh S. Pharmacogenetics of nonsteroidal anti-inflammatory drugs. Pharmacogenomics J. 2012;12:462–7.

    Article  CAS  PubMed  Google Scholar 

  9. World Health Organization (WHO). National Cancer Control Programmes: policies and managerial guidelines. 3rd ed. Geneva; 2002. Available from: http://whqlibdoc.who.int/hq/2002/9241545577.pdf. Last access on 14 Feb 2013.

  10. Horlocker TT, Wedel DJ, Rowlingson JC, et al. Regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy: American Society of regional anesthesia and pain medicine evidence-based guidelines (3rd ed). Reg Anesth Pain Med. 2010;35(1):64–101.

    Article  CAS  PubMed  Google Scholar 

  11. Rosenecher N, Bottet M, Sessler D. Selected new antithrombotic agents and neuraxial anesthesia for major orthopaedic surgery: management strategies. Anaesthesia. 2007;62:1154–60.

    Article  Google Scholar 

  12. Novak E, Allen PJ. Prescribing medications in pediatrics: concerns regarding FDA approval and pharmacokinetics. Pediatr Nurs. 2007;33:64–70.

    PubMed  Google Scholar 

  13. Committee on Infectious Diseases, American Academy of Pediatrics. Pickering LK, editor. 2012. Red Book®: 2012 Report of the Committee on infectious diseases – 29th ed. 2012. Printed in the United States of America. American Academy of Pediatrics. ISBN-10: 1-58110-703-X, ISBN-13: 978-1-58110-703-6. ISSN: 1080-0131. STAT!Ref Online Electronic Medical Library. http://online.statref.com/document.aspx?fxid=76&docid=58. 2/13/2013 4:12:28PM CST (UTC -06:00).

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Authors and Affiliations

  1. Department of Anesthesiology, Albert Einstein School of Medicine – Yeshiva University, Montefiore Medical Center, Bronx, NY, USA

    My Tu MD, Karina Gritsenko MD, Boleslav Kosharskyy MD & Naum Shaparin MD

  2. Department of Family and Social Medicine, Albert Einstein School of Medicine – Yeshiva University, Montefiore Medical Center, Bronx, NY, USA

    Karina Gritsenko MD & Naum Shaparin MD

Authors
  1. My Tu MD
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  2. Karina Gritsenko MD
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  3. Boleslav Kosharskyy MD
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  4. Naum Shaparin MD
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Corresponding author

Correspondence to My Tu MD .

Editor information

Editors and Affiliations

  1. Departments of Anesthesiology and Pharmacology, LSU Health Sciences Center, New Orleans, Louisiana, USA

    Alan David Kaye

  2. Department of Pharmacy Practice, Thomas J. Long School of Pharmacy and Health Sciences, Stockton, California, USA

    Adam M. Kaye

  3. Center for Perioperative Management and Medical Informatics, Brigham and Women’s Hospital, Boston, Massachusetts, USA

    Richard D. Urman

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Tu, M., Gritsenko, K., Kosharskyy, B., Shaparin, N. (2015). Antipyretics: Acetaminophen, Arachidonic Acid Agents, and COX1 and COX2 Inhibitors. In: Kaye, A., Kaye, A., Urman, R. (eds) Essentials of Pharmacology for Anesthesia, Pain Medicine, and Critical Care. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8948-1_27

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  • DOI: https://doi.org/10.1007/978-1-4614-8948-1_27

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-8947-4

  • Online ISBN: 978-1-4614-8948-1

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